PSMB2 Antibody
Shipped with Ice Packs 
In Stock 
Product Specs
Buffer
The antibody is supplied in PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. It should be stored at -20°C and freeze/thaw cycles should be avoided.
Lead Time
Typically, we can ship the products within 1-3 business days after receiving your order. Delivery time may vary depending on the purchase method or location. Please consult your local distributors for specific delivery times.
Synonyms
HC7 I antibody; Macropain subunit C7 I antibody; Macropain subunit C7-I antibody; Multicatalytic endopeptidase complex subunit C7 1 antibody; Multicatalytic endopeptidase complex subunit C7 I antibody; Multicatalytic endopeptidase complex subunit C7-I antibody; Proteasome (prosome, macropain) subunit beta type 2 antibody; Proteasome beta 2 subunit antibody; Proteasome component C7 I antibody; Proteasome component C7-I antibody; Proteasome subunit beta type-2 antibody; PSB2_HUMAN antibody; Psmb2 antibody
Target Names
PSMB2
Uniprot No.
Target Background
Function
PSMB2, also known as β2 subunit, is a non-catalytic component of the 20S core proteasome complex. This complex is essential for the proteolytic degradation of most intracellular proteins. It plays crucial roles within the cell by interacting with different regulatory particles. When associated with two 19S regulatory particles, it forms the 26S proteasome and participates in the ATP-dependent degradation of ubiquitinated proteins. This process is critical for maintaining protein homeostasis by removing misfolded or damaged proteins, preventing disruptions to cellular functions, and eliminating proteins whose functions are no longer required. The 20S proteasome can also associate with PA200 or PA28, mediating ubiquitin-independent protein degradation. This type of proteolysis is involved in various pathways, including spermatogenesis (20S-PA200 complex) and the generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
Gene References Into Functions
- Studies have shown that overexpression of the β2 subunit reduces homologous recombination in human cells without affecting the cell proteasome activity or Rad51p levels. PMID: 21660142
- The propeptides of this subunit influence the cooperative assembly of the proteasome. PMID: 12456675
Database Links
Protein Families
Peptidase T1B family
Subcellular Location
Cytoplasm. Nucleus.
Quick Inquiry
Personal Email Detected
Please use an institutional or corporate email address for inquiries. Personal email accounts ( such as Gmail, Yahoo, and Outlook) are not accepted. *
