sel-12 Antibody
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In Stock 
Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
sel-12 antibody; F35H12.3 antibody; Presenilin sel-12 antibody; Suppressor/enhancer of lin-12 protein 12 antibody
Target Names
sel-12
Uniprot No.
Target Background
Function
SEL-12 is a probable catalytic subunit of the gamma-secretase complex. This complex is an endoprotease that catalyzes the intramembrane cleavage of integral membrane proteins, such as Notch receptors (lin-12 or glp-1). SEL-12 plays a crucial role in presenilin function, distinguishing it from hop-1 and spe-4. It is required cell-autonomously for proper neurite connectivity of the AIY cholinergic interneurons and their correct functioning in thermotaxis. SEL-12 is also essential for mesodermal patterning of muscle function. Furthermore, it promotes basement membrane gap formation during tissue remodeling.
Gene References Into Functions
- Mutations in sel-12 lead to defects in calcium homeostasis, resulting in mitochondrial dysfunction. PMID: 26500256
- A genetic null allele mutant, sel-12(ar171), exhibits resistance to oxidative stress and prevents mitochondrial dysfunction-induced apoptosis. PMID: 12556527
Database Links
Protein Families
Peptidase A22A family
Subcellular Location
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Tissue Specificity
Expressed in most neurons.
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