pat2-k2 Antibody

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Description

PAT2 (Proton-Assisted Amino Acid Transporter 2)

A lysosomal membrane protein involved in amino acid sensing and regulation of mTORC1 signaling in adipocytes . Key characteristics include:

PropertyDetails
Gene SymbolSLC36A2
Cellular LocalizationLysosomes (preadipocytes), Plasma membrane (mature adipocytes)
FunctionRegulates vATPase assembly, lysosomal acidification, and amino acid-dependent mTORC1 activation
Experimental ToolsStudied via HA-tagged overexpression and shRNA knockdown models

Recent studies demonstrate PAT2 translocates between lysosomes and plasma membrane depending on amino acid availability, influencing cellular metabolism .

K2 Antibody

A well-characterized monoclonal antibody targeting double-stranded RNA (dsRNA):

Research Applications:

  • Detects viral replication intermediates (e.g., Hepatitis C, Dengue, SARS-CoV-2)

  • Quantifies dsRNA in sandwich ELISA formats

  • Used in >200 studies since 1991 for RNA structure analysis

Analysis of Potential Term Confusion

The term "pat2-k2" likely results from either:

  1. Typographical error (e.g., intended "PAT2" or "K2" separately)

  2. Misinterpretation of antibody catalog numbers (e.g., Jena Bioscience's RNT-SCI-10030-K2)

  3. Improper concatenation of PAT2 protein studies with K2 antibody technical specifications

Suggested Alternatives for Further Investigation

  1. PAT2-Specific Research Tools

    • Custom PAT2 antibodies: Requires epitope mapping against extracellular domains (aa 1-50 or 450-500)

    • Commercial PAT2 cDNA clones (e.g., GenBank NM_001329145)

Product Specs

Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M Phosphate Buffered Saline (PBS), pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
pat2-k2 antibody; Patatin-2-Kuras 2 antibody; EC 3.1.1.- antibody
Target Names
pat2-k2
Uniprot No.

Target Background

Function
Probable lipolytic acyl hydrolase (LAH) is an enzyme believed to play a role in the defense response of tubers against pathogens.
Database Links

UniGene: Stu.20733

Protein Families
Patatin family
Subcellular Location
Vacuole.

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