clr-1 Antibody

Preservative: 0.03% ProClin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Liquid

Made-to-order (14-16 weeks)

clr-1 antibody; F56D1.4 antibody; Receptor-type tyrosine-protein phosphatase antibody; EC 3.1.3.48 antibody

clr-1

H2KZM6

CLR-1, a receptor protein tyrosine phosphatase (RPTP), exhibits intrinsic protein tyrosine phosphatase (PTPase) activity. It regulates egl-15 activity, crucial for hypodermis-mediated fluid homeostasis and muscle protein degradation. During larval neuromuscular junction formation, CLR-1 negatively regulates membrane protrusion from body wall muscles. Furthermore, it plays a role in nicotinic acetylcholine receptor (nAChR)-mediated nicotine sensitivity and regulates synaptic levels of the nAChR subunit LEV-1 in the nerve cord. CLR-1 promotes the outgrowth of PVD sensory neuron quaternary dendritic branches and, in parallel with the sax-7/mnr-1 pathway, controls PVD primary branch extension. It functions within the netrin/DCC pathway, mediating synapse formation between AVA interneurons and PHB sensory neurons, and is also required for synapse formation between AVA interneurons and VA10 motor neurons.

• CLR-1 is essential for synaptic partner recognition (SPR) between PHB sensory neurons and AVA interneurons. PMID: 29742100
• In C. elegans skin cells, CLR-1 promotes sensory dendrite outgrowth. PMID: 26968353

KEGG: cel:CELE_F56D1.4

STRING: 6239.F56D1.4b

UniGene: Cel.14960

Protein-tyrosine phosphatase family, Receptor class 2A subfamily

Cell membrane; Single-pass membrane protein. Cell junction, synapse.

Expressed in muscles, hypodermis and a subset of neurons. Expressed in the AVA neurons, with high expression in the anterior half of the preanal ganglion where AVA neurons contact the PHB neurons.