puf-5 Antibody
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In Stock 
Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
puf-5 antibody; F54C9.8 antibody; Pumilio domain-containing protein 5 antibody
Target Names
puf-5
Uniprot No.
Target Background
Function
PUF-5 is an RNA-binding protein that interacts with the consensus sequence 5'-CUCUGUAUCUUGU-3' within mRNA 3'-UTRs. This interaction plays a crucial role in regulating mRNA expression and stability. PUF-5 exhibits functional redundancy with puf-6 and puf-7 in processes such as oocyte formation and organization, early embryonic cell divisions, and the repression of glp-1 and other maternal mRNA transcripts during late oogenesis.
Gene References Into Functions
- The PUF domain protein PUF-5, along with two highly similar PUF proteins, PUF-6 and PUF-7, are involved in the repression of glp-1 and other maternal mRNAs during a specific stage of oocyte differentiation. PMID: 17234175
- PUF-5 and PUF-6 exhibit recognition of similar RNA sequences, distinct from those recognized by members of the FBF and PUF-8/-9 groups. PUF-5, PUF-6, and PUF-7 collectively regulate overlapping (or identical) sets of target mRNAs. PMID: 18579869
Database Links
Subcellular Location
Cytoplasm. Cytoplasm, P-body.
Tissue Specificity
Detected in differentiating oocytes with highest levels observed in developing ooctyes in the distal portion of the proximal gonad.
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