Function
PUMPs are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thereby uncoupling oxidative phosphorylation. This results in a decrease in the efficiency of oxidative phosphorylation and an increase in heat production. PUMPs may be involved in protecting plant cells from oxidative stress damage. Recombinant PUMP5, reconstituted into liposomes, transports a wide range of dicarboxylic acids, including malate, oxaloacetate, and succinate, as well as phosphate, sulfate, and thiosulfate. However, the biological significance of these transports in vivo remains to be determined.