PUR2 Antibody

Definition and Target

PAR2 (Protease-Activated Receptor 2) is a G-protein-coupled receptor involved in inflammation, cancer progression, and cellular signaling. Antibodies targeting PAR2 are primarily used to study its expression and function in diseases such as cancer and inflammatory disorders.

Key Features of PAR2 Antibodies:

• Clone specificity: Mouse monoclonal antibodies (e.g., Clone 344222) .

• Applications: Flow cytometry, immunocytochemistry, and membrane protein staining .

• Target epitope: Extracellular domain of human PAR2 (Accession #P55085) .

Research Applications and Validation

While PAR2 itself is implicated in cancer metastasis and inflammatory responses, the search results highlight PLA2R antibodies (Phospholipase A2 Receptor) as another critical area of research:

• Diagnostic utility: Serum anti-PLA2R antibodies are biomarkers for primary membranous nephropathy (PMN), with levels >226 RU/mL distinguishing PMN from secondary forms (SMN) .

• Prognostic value: Higher baseline anti-PLA2R levels correlate with delayed remission (67% remission in antibody-negative vs. 13% in antibody-positive patients post-treatment) .

Comparative Antibody Landscape

Broader Implications in Antibody Research

• SARS-CoV-2 applications: Antibody engineering methods like LIBRA-seq enable isolation of broadly reactive antibodies, including those against future viral variants .

• Antibody validation: Techniques such as peptide microarrays (e.g., mapping 79 SARS-CoV-2 epitopes ) underscore the importance of epitope characterization for diagnostic accuracy.