rab-10 Antibody
Description
Biological Functions of Rab10
Rab10 regulates vesicular transport, receptor trafficking, and cellular signaling through GTPase activity. Key functions include:
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TLR4 signaling modulation: Rab10 promotes TLR4 transport from the Golgi to the plasma membrane, amplifying LPS-induced inflammatory responses (e.g., TNF-α, IL-6) and exacerbating acute respiratory distress syndrome (ARDS) in vivo .
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Neuronal trafficking: Facilitates retrograde transport of TrkB receptors in hippocampal neurons, critical for BDNF signaling and axonogenesis .
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Cancer progression: Overexpression in breast cancer (BC) and hepatocellular carcinoma (HCC) correlates with poor prognosis, HER2 status, and proliferation via oncogenic pathways .
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LRRK2 phosphorylation: Phosphorylation at Thr-73 by LRRK2 regulates ciliogenesis, lysosomal stability, and Parkinson’s disease-related pathways .
Research Applications of Rab10 Antibodies
Rab-10 antibodies are widely used in:
Neurodegenerative Diseases
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LRRK2-Rab10 interaction: Phospho-specific antibodies (e.g., MJFF-pRAB10) confirmed Rab10 phosphorylation at Thr-73 in Parkinson’s models, linking it to disrupted vesicular trafficking .
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Neuronal trafficking defects: Knockdown of Rab10 in hippocampal neurons impaired TrkB receptor retrograde transport, reducing BDNF signaling .
Cancer Mechanisms
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Breast cancer: RAB10 upregulation in BC tissues correlated with HER2 positivity and immune infiltration (CIBERSORT analysis) .
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HCC progression: shRNA-mediated Rab10 knockdown in HepG2 cells reduced proliferation and survival via apoptosis pathways .
Inflammatory Regulation
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TLR4-mediated ARDS: Rab10 overexpression in macrophages increased LPS-induced lung injury, highlighting its role as a therapeutic target .
Clinical and Therapeutic Implications
Rab10 antibodies have identified its involvement in:
Product Specs
Target Background
PMID: 22869721, This research identifies a Rab10-to-ARF-6 regulatory loop that controls endosomal PI(4,5)P2, a key phosphoinositide in membrane traffic., .
PMID: 16394106, This publication establishes Rab10 as a key regulator of endocytic recycling upstream of RME-1 in polarized epithelial cells of the *C. elegans* intestine., .
PMID: 17761527, This work shows that Rab10 and LIN-10 recycle AMPA-type glutamate receptors from intracellular endosomal compartments to synapses via distinct pathways., .
