RAB11A Antibody

1. Irregularly coated vesicle formation is observed exclusively in influenza A virus infected cells and necessitates an active Rab11 GTPase. PMID: 29123131
2. This study proposes that Rab11a acts as a crucial oncoprotein and regulator of YAP in human non-small cell lung cancer. PMID: 28468127
3. This review examines the structure and function of the novel Rab11-FIP3-Rabin8 dual effector complex and its implications for targeting sensory receptors to primary cilia. Dysfunctional cilia are linked to ciliopathies, a group of human diseases and disorders. PMID: 26399276
4. Data suggest that membrane tethering mediated by endosomal RAB11A is significantly and selectively stimulated by its cognate Rab effectors, class V myosins (MYO5A and MYO5B), in a GTP-dependent manner. (RAB11A = ras-related GTPase Rab-11A; MYO5 = myosin class V) PMID: 28939769
5. These studies are the first to identify the alpha4 helix of Rab11a as a protein binding domain on the GTPase. They provide novel mechanistic insights into the intracellular trafficking of the hIP, and potentially of other members of the GPCR superfamily, involving Rab11-dependent mechanisms. PMID: 28739266
6. Transient expression of ATG16L1 not only inhibited autophagosome biogenesis, but also aberrantly targeted RAB11-positive recycling endosomes, resulting in recycling endosome aggregates. PMID: 27875067
7. The results from this analysis indicated that Rab11a, Rab11c(Rab25) and Rab14 were expressed in a wide range of cell lines, including the human placental trophoblastic BeWo cell line. PMID: 28922401
8. The results suggest that progressive assembly of vRNA segments may be cell type dependent and that vRNA may be transported through the cytoplasm without Rab11A-containing recycling endosomes in the absence of intact microtubules. PMID: 28724771
9. Rac1-Rab11-FIP3 regulatory hub coordinates vesicle traffic with actin remodeling and T-cell activation PMID: 27154205
10. In colorectal carcinoma, overexpression of Rab11 was found to promote collective cell migration through the increased distribution of E-cadherin, which enhanced cell-cell connections. PMID: 27696383
11. A novel tribasic Golgi export signal directs cargo protein interaction with activated Rab11 and AP-1-dependent Golgi-plasma membrane trafficking. PMID: 26941330
12. Analysis reveals novel aspects of the PI4KIIIb-Rab11 complex, specifically conformational changes induced in the switch regions of activated Rab11. PMID: 26756197
13. Substituted V20 of Rab11A was found to interfere with proper localization of the water molecule, which mediated GTP hydrolysis, resulting in GTP being locked in an active form of Rab11A S20V. PMID: 26879265
14. Data (including data from studies in knockout mice) suggest Munc13-4 binds to Rab11 and regulates trafficking of Rab11-containing vesicles; Munc13-4 appears to regulate final steps of Rab11-positive vesicle docking at plasma membrane in exocytosis. PMID: 26637356
15. Rab11A and Rab11B differentially regulate intracellular trafficking of PAR1 through distinct endosomal sorting mechanisms PMID: 26635365
16. Rab11a/Rab11 family-interacting protein 2-mediated VE-cadherin recycling is required for formation of adherens junctions and restoration of vascular endothelial barrier integrity. PMID: 26663395
17. Mumps Virus release from the apical surface of polarized epithelial cells is facilitated by a Rab11-mediated transport system. PMID: 26378159
18. Vaccinia virus traffics to early endosomes, where recycling endosome markers Rab11 and Rab22 are recruited to participate in subsequent virus trafficking prior to virus core uncoating in the cytoplasm. PMID: 26041286
19. Rab11a-knockdown cells displayed mislocalization of STX3 and the presentation of microvilli in the basolateral compartment PMID: 25673875
20. Rab11 co-localizes with alpha-synuclein in intracellular inclusions and modulates its aggregation, secretion and toxicity. PMID: 25092884
21. PI4KIIIbeta likely plays a role in breast oncogenesis and that cooperation between Rab11a and PI4KIIIbeta represents a novel Akt activation pathway. PMID: 24962317
22. Additionally, Rab11 recruitment is absent and Shigella-containing vacuolar rupture is delayed in the ipgD mutant that does not dephosphorylate PI(4,5)P2 into PI(5)P. PMID: 25299335
23. Data demonstrated that Rab11 regulated E-cadherin expression and promoted colon cancer cell transformation. PMID: 25117932
24. Rab11-dependent EGFR recycling has a role in synergistic cytotoxicity of afatinib and cetuximab against EGFR T790M PMID: 25446083
25. Microvilli establishment required interaction between RAB8A and MYO5B, while loss of the interaction between RAB11A and MYO5B induced microvillus inclusions. PMID: 24892806
26. Ubiquitylation and activation of RAB11a is promoted by a beta2 adrenergic receptor-HACE1 complex. PMID: 24190883
27. Rab11A controls BACE1 recycling to endosomes and thus affects beta-amyloid production. PMID: 24373285
28. These data provide a mechanism for how PI4KIIIbeta coordinates Rab11 and its effectors on PI4P-enriched membranes and also provide strategies for the design of specific inhibitors that could potentially target plasmodial PI4KIIIbeta to combat malaria. PMID: 24876499
29. Mitochondrial remodeling was associated with increased proximity between Rab11a and mitochondrial membranes, changes in fusion-fission dynamics, and mitochondrial relocalization of the Drp1, which was regulated by the Rab11a effector protein FIP1/RCP. PMID: 24302731
30. Data indicate that alpha2-macroglobulin (alpha2M*), through its receptor LRP1, induces cellular migration of Muller glial cells by a mechanism that involves MT1-MMP intracellular traffic to the plasma membrane by a Rab11-dependent recycling pathway. PMID: 23640058
31. Dominant negative (GDP-locked)-Rab5 and -Rab11 reproduced the effects of inhibitors of tubulin and actin, respectively, on the cycling of bradykinin B receptor. PMID: 23454239
32. These findings suggest that Rab11-FIP1 proteins participate in spatially and temporally distinct steps of the recycling process along a complex and dynamic tubular network in which Rab11-FIPs occupy discrete domains. PMID: 23283983
33. The potential roles of the Rab11 pathway in the trafficking, assembly and budding steps of negative-strand viruses. PMID: 23176490
34. Rab11 depletion gives rise to accumulation of recycling carriers containing endocytosed transferrin and transferrin receptor beneath the plasma membrane. PMID: 22685325
35. Findings show 2 mother centriole appendage proteins, centriolin and cenexin/ODF2, regulate association of the endosome components Rab11, the Evi5, and the exocyst at the mother centriole PMID: 22981775
36. Rab11A/myosin Vb/Rab11-FIP2 complex frames two late recycling steps of langerin from the ERC to the plasma membrane PMID: 22420646
37. TBC1D14 binds activated Rab11 but is not a GAP for Rab11, and loss of Rab11 prevents TBC1D14-induced tubulation of recycling endosomes. PMID: 22613832
38. Our data suggest a selective role of PICK1 in clustering and reducing the recycling rates of PDZ domain binding partners sorted to the Rab11-dependent recycling pathway. PMID: 22303009
39. Recycling was accompanied by dephosphorylation of VEGFR-2 between Rab4 and Rab11 vesicles and quantitatively and qualitatively altered signal output. PMID: 21586748
40. Our results uncover a critical host factor with an essential contribution to influenza virus genome delivery and reveal a potential role for RAB11A in the transport of ribonucleoprotein cargo. PMID: 21525351
41. The authors propose that influenza virus ribonucleoproteins are routed from the nucleus to the pericentriolar recycling endosome (RE), where they access a Rab11-dependent vesicular transport pathway to the cell periphery. PMID: 21307188
42. Rabin8 and Rab11 are associated with the Bardet-Biedl syndrome. PMID: 21273506
43. Rab11a, but not Rab8a, is required for recycling of transferrin in nonpolarized cells. PMID: 21282656
44. Rab11a played a prominent role in recycling of the wild type ss1-adrenergic receptors because dominant negative rab11a inhibited. PMID: 20727405
45. Rab11a is an important regulator of TLR4 and Toll-receptor-associated molecule transport to E. coli phagosomes thereby controlling IRF3 activation from this compartment. PMID: 20933442
46. Mutant prion protein expression is associated with an alteration of the Rab GDP dissociation inhibitor alpha (GDI)/Rab11 pathway. PMID: 19996123
47. Results describe the involvement of two Rab GTPases, Rab9 and Rab11, in the trafficking of TRPC6. PMID: 20346379
48. Transmission electron microscopy of thin sections confirmed that Rab11 depletion resulted in significant numbers of abnormally formed virus particles that had failed to pinch off from the plasma membrane. PMID: 20357086
49. Rab11, in its GTP-bound form, interacts with Rabin8 and kinetically stimulates the guanine nucleotide-exchange activity of Rabin8 toward Rab8. PMID: 20308558
50. Mutation impairs a specific subset of Rab11 interactions, possibly those involved in cytoskeleton-based movements driving the slow recycling pathway PMID: 14699104

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HGNC: 9760

OMIM: 605570

KEGG: hsa:8766

STRING: 9606.ENSP00000261890

UniGene: Hs.321541