RAB34 Antibody
Description
Cancer Biology
RAB34 overexpression is linked to aggressive tumor phenotypes in glioma, hepatocellular carcinoma (HCC), and non-small cell lung cancer (NSCLC) . Studies using RAB34 Antibody demonstrate:
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Glioma: RAB34 expression correlates with tumor grade, immune infiltration, and poor prognosis. Inhibition of RAB34 reduces glioma cell migration and epithelial-to-mesenchymal transition (EMT) .
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HCC: Suppression of RAB34 via siRNA decreases cell proliferation and EMT markers (e.g., N-cadherin downregulation) .
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NSCLC: RAB34 promotes tumorigenesis and metastasis by regulating integrin recycling .
Ciliogenesis and Ciliopathies
Pathogenic RAB34 variants impair primary cilium assembly, causing syndromes like OFDS (Orofaciodigital Syndrome) . Functional studies with RAB34 Antibody reveal:
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Ciliary Defects: Mutant RAB34 proteins fail to rescue ciliogenesis in KO cells, highlighting its role in ciliary vesicle formation .
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Hedgehog Signaling: RAB34 disruption disrupts Hedgehog pathway activation, critical for embryonic development .
Intracellular Trafficking
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Lysosome Repositioning: RAB34 localizes to Golgi and induces lysosome clustering, facilitating phagosome-lysosome fusion .
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Macropinocytosis: RAB34 activates this bulk fluid uptake mechanism, aiding nutrient acquisition in cancer cells .
Clinical and Diagnostic Potential
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Biomarker: Elevated RAB34 expression in glioma and HCC tissues correlates with poor survival, suggesting its utility as a prognostic marker .
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Therapeutic Target: Inhibiting RAB34 may disrupt cancer cell growth and immune evasion .
Data Table: RAB34 Antibody Validation
Product Specs
Target Background
- Research indicates that RAB34 plays a significant role in the initiation and progression of hepatocellular carcinoma (HCC). These findings suggest a potential new therapeutic target for the clinical treatment of HCC. PMID: 29048615
- Rab34 activity is modulated by SopD2 and is essential for the maturation of the Salmonella containing vacuole. PMID: 28185347
- NARR is ubiquitously expressed and localizes to nucleoli where it colocalizes with ribosomal DNA gene clusters. PMID: 21586586
- MMP19 exhibits a positive correlation with RAB34. PMID: 25501506
- While Rab34 regulates both lysosomal positioning and lysosome to phagosome fusion, the latter effect is not attributed to the regulation of cytoplasmic accessibility of lysosomes to phagosomes by Rab34. PMID: 23871933
- Rab36 potentially regulates the spatial distribution of late endosomes and lysosomes through a mechanism similar to Rab34. PMID: 19961360
- Data suggest that diacylglycerol-activated hmunc13 acts as an effector of Rab34, mediating lysosome-Golgi trafficking. PMID: 16138900
- Rab34 is identified as a novel member of the secretory pathway operating at the Golgi. PMID: 17881736
- Coxsackievirus B entry relies on occludin and requires the activity of Rab34, Ras, and Rab5, GTPases known to regulate macropinocytosis. PMID: 18005733
- The mechanistic basis for high glucose-induced protein secretion is through the interaction of munc13 and rab34, indicating a potentially critical role for this newly described pathway in the pathogenesis of diabetic nephropathy. PMID: 19641095
