RAB39A Antibody, HRP conjugated
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In Stock 
Product Specs
Buffer
**Preservative:** 0.03% Proclin 300
**Constituents:** 50% Glycerol, 0.01M PBS, pH 7.4
**Constituents:** 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
We typically dispatch products within 1-3 business days of receiving your order. Delivery times may vary depending on the shipping method and destination. For specific delivery timeframes, please consult your local distributor.
Synonyms
rab related GTP binding protein antibody; Rab-39 antibody; Rab39 antibody; RAB39A antibody; RAB39A member RAS oncogene family antibody; Ras related protein Rab39A antibody; Ras-related protein Rab-39A antibody; RB39A_HUMAN antibody
Target Names
RAB39A
Uniprot No.
Target Background
Function
RAB39A plays a crucial role in the maturation and acidification of phagosomes that engulf pathogens, including *Staphylococcus aureus* and *Mycobacterium tuberculosis*. It is also involved in vesicular trafficking and the fusion of phagosomes with lysosomes. RAB39A negatively regulates lipopolysaccharide (LPS)-induced autophagosome formation in macrophages, potentially through the PI3K pathway. Additionally, RAB39A may participate in multiple neurite formation processes.
Gene References Into Functions
- Molecular pathways regulated by RAB39A are transcriptionally maintained through the formation of a molecular complex with RXRB, NCOR, and HDAC. This complex also contributes to cancer stemness. PMID: 29648608
- C9ORF72 is associated with suboptimal autophagy. PMID: 27494456
- Research indicates that Rab39a promotes chlamydial replication and infectivity. This is the first report demonstrating the involvement of a late endocytic Rab GTPase in the development of chlamydial infection. PMID: 26163492
- Findings suggest that Rab39a interacts with caspase-1 and acts as a trafficking adaptor linking caspase-1 to IL-1beta secretion. PMID: 19833722
Database Links
Protein Families
Small GTPase superfamily, Rab family
Subcellular Location
Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Lysosome. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis.
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