RAB3IP Antibody
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Product Specs
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. Store at -20°C. Avoid repeated freeze-thaw cycles.
Lead Time
Typically, we can ship your orders within 1-3 business days of receipt. Delivery times may vary depending on the purchase method or location. Please consult your local distributor for specific delivery time estimates.
Synonyms
Gtpat12 antibody; Rab-3A-interacting protein antibody; RAB3A interacting protein antibody; RAB3A interacting protein (rabin3) antibody; RAB3A interacting protein antibody; RAB3A-interacting protein antibody; RAB3I_HUMAN antibody; Rab3ip antibody; Rabin 3 antibody; Rabin-3 antibody; RABIN3 antibody; RABIN3; rat; homolog of antibody; Rabin8 antibody; SSX2 interacting protein antibody; SSX2 interacting protein antibody; SSX2-interacting protein antibody
Target Names
RAB3IP
Uniprot No.
Target Background
Function
RAB3IP is a guanine nucleotide exchange factor (GEF) that activates RAB8A and RAB8B. It promotes the exchange of GDP for GTP, converting inactive GDP-bound Rab proteins to their active GTP-bound form. RAB3IP facilitates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5. This GEF modulates actin organization and promotes the polarized transport of RAB8A-specific vesicles to the cell surface. In collaboration with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42, and DNMBP, RAB3IP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation, and lumenogenesis.
Gene References Into Functions
- Research indicates that Rab11-GMPPNP-FIP3-Rabin8 is more stable than Rab11-GMPPNP-Rabin8 due to direct interaction between Rabin8 and FIP3 within the dual effector-bound complex. PMID: 26258637
- Studies have examined the role of Rabin8 (a mammalian ortholog of Sec2p) with Rab8-nucleotide-exchange factor activity in autophagy in mammalian cells. PMID: 25787272
- Rab11-FIP3 coordinates the interactions of ASAP1 and Rab11a with Rabin8. PMID: 25673879
- Rabin8 has been identified as a direct phospho-substrate of ERK1/2 in response to EGF signaling. PMID: 25535387
- RABIN3 interacts with the cancer-related protein SSX2 and a novel nuclear protein, SSX2IP. PMID: 12007189
Database Links
Protein Families
SEC2 family
Subcellular Location
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Vesicle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Tissue Specificity
Expressed in brain, kidney, heart, pancreas and placenta. Not detected in skeletal muscle or liver.
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