ITGA7 Antibody

• It is hypothesized that the postnatal splicing of alpha7A to alpha7B and of beta1A to beta1D integrins is delayed, potentially altering the spontaneous descent of the testes in the early months of life. PMID: 30089289
• As knockdown of Integrin alpha7 (ITGA7) effectively reduces the stemness of oesophageal squamous cell carcinoma (OSCC) cells, ITGA7 could serve as a potential therapeutic target for OSCC treatment. PMID: 27924820
• Targeting of ITGA7 by RNAi or blocking mAbs impaired laminin-induced signaling, leading to a significant delay in tumor engraftment and a notable reduction in tumor size and invasion. PMID: 28602620
• Findings further support the use of a7 integrin as a potential therapeutic strategy for Duchenne muscular dystrophy. PMID: 26076707
• Data suggest that S100 calcium binding protein P (S100P) enhances lung cancer cell migration by binding integrin alpha7. PMID: 26320193
• Evidence indicates that ITGA7 is an epigenetically regulated tumor suppressor gene and a prognostic factor in human malignant pleural mesothelioma. PMID: 26011651
• ITGA7 binds to tissue inhibitor of metalloproteinase 3 (TIMP3) in prostate cancer cells. PMID: 23830872
• The absence of either alpha7beta1 integrin or alpha6beta1 integrin hinders the ability of Schwann cells to spread and bind laminin. PMID: 24227711
• Digenic mutational inheritance of the integrin alpha 7 and the myosin heavy chain 7B genes causes congenital myopathy with left ventricular non-compact cardiomyopathy. [ITGA7] PMID: 23800289
• Alpha7beta1D integrin modifies Ca2+ regulatory pathways and provides a mechanism to protect the myocardium from ischemic injury. PMID: 24091324
• This report provides a novel insight into the mechanism, involving interaction with high temperature requirement A2, by which ITGA7 acts as a tumor suppressor. PMID: 20651226
• ILK interaction with MCM7 and MCM7 phosphorylation may be a crucial event in the ITGA7 signaling pathway, leading to tumor suppression. PMID: 20460506
• It is concluded that secondary integrin alpha 7 deficiency is relatively common in muscular dystrophy/myopathy of unknown etiology. PMID: 12057917
• FHL2 and FHL3, respectively, are colocalized with alpha(7)beta(1) integrin receptor at the periphery of Z-discs, suggesting a role in the mechanical stabilization of muscle cells. PMID: 15117962
• Alpha7-expressing fetal myoblasts are capable of differentiation to the osteoblast lineage with a coordinated switch in integrin profiles, potentially representing a mechanism that promotes homing and recruitment of myogenic stem cells for tissue remodeling. PMID: 17054947
• Integrin alpha7 mutations have been linked to prostate cancer, liver cancer, glioblastoma multiforme, and leiomyosarcoma. PMID: 17551147
• Analysis reveals how distinct acidic clusters and hydrophobic residues within the alternative splice domains X1 and X2 of alpha7 integrins define specificity for laminin isoforms. PMID: 17618648
• Alpha7B is a novel marker of the contractile phenotype, and alpha7 expression is crucial for human airway smooth muscle cell maturation, a laminin-dependent process. PMID: 17641293
• Cleavage is a novel mechanism that regulates alpha7 integrin functions in skeletal muscle, and the generation of such cleavage sites represents another evolutionary mechanism for expanding and modifying protein functions. PMID: 18940796
• Laminin-111 (alpha(1), beta(1), gamma(1)), which is expressed during embryonic development but absent in normal or dystrophic skeletal muscle, increased alpha(7)-integrin expression in mouse and DMD patient myoblasts. PMID: 19416897

HGNC: 6143

OMIM: 600536

KEGG: hsa:3679

STRING: 9606.ENSP00000452120

UniGene: Hs.524484