RASA3 Antibody
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Product Specs
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. Stored at -20°C. Avoid freeze-thaw cycles.
Lead Time
Typically, we can ship products within 1-3 business days of receiving your order. Delivery time may vary depending on the method of purchase and destination. Please consult your local distributors for specific delivery timelines.
Synonyms
GAP III antibody; GAP1(IP4BP) antibody; GAP1IP4BP antibody; GAPIII antibody; GTPase activating protein 1 family antibody; GTPase activating protein III antibody; Inositol 1 3 4 5 tetrakisphosphate binding protein antibody; Inositol 1345 tetrakisphosphate binding protein antibody; Ins P4 binding protein antibody; Ins P4-binding protein antibody; Ins(1 3 4 5)P4 binding protein antibody; Ins(1345)P4 binding protein antibody; MGC46517 antibody; MGC47588 antibody; Ras GTPase activating protein 3 antibody; Ras GTPase-activating protein 3 antibody; RAS p21 protein activator 3 antibody; RASA 3 antibody; RASA3 antibody; RASA3_HUMAN antibody
Target Names
Uniprot No.
Target Background
Function
RASA3 acts as an inhibitory regulator within the Ras-cyclic AMP signaling pathway. It exhibits high-affinity binding to inositol tetrakisphosphate (IP4) and may function as a specific IP4 receptor.
Gene References Into Functions
- Rasa3 plays a crucial role in regulating Rap1 activity in endothelial cells, influencing their adhesion properties and vascular lumen integrity. Specific inactivation of Rasa3 within endothelial cells leads to occluded blood vessels, hemorrhages, and early embryonic death in mice, mirroring the phenotype observed in Rasa3-/- mice. PMID: 29381707
- These findings underscore the significant role of Rasa3 in PI3K-dependent integrin alphaIIbbeta3-mediated outside-in signaling and cell spreading. PMID: 27903653
- The function of RASA3 has been established in megakaryopoiesis, megakaryocyte adhesion and migration, as well as integrin signaling. PMID: 25294679
- RASA3 is implicated in intracellular calcium homeostasis. PMID: 12356770
- A proposed model suggests that the Ras GAP-related domain of GAP1(IP4BP) stabilizes the switch II region of Rap1, facilitating stabilization of the transition state during GTP hydrolysis initiated by the arginine finger. PMID: 19433443
- GAP1IP4BP serves as an inositol 1,3,4,5-tetrakisphosphate-regulated plasma membrane-associated Ras and Rap GAP. Its membrane association arises from the binding of its PH domain to phosphatidylinositol 4,5-bisphosphate. PMID: 7637787
Database Links
Subcellular Location
Cell membrane.
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