RBP3 Antibody, HRP conjugated
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Product Specs
Buffer
**Preservative:** 0.03% Proclin 300
**Constituents:** 50% Glycerol, 0.01M PBS, pH 7.4
**Constituents:** 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Typically, we can ship your order within 1-3 business days after receiving it. Delivery times may vary depending on the purchase method and location. Please contact your local distributor for specific delivery information.
Synonyms
D10S64 antibody; D10S65 antibody; D10S66 antibody; Interphotoreceptor retinoid binding protein antibody; Interphotoreceptor retinoid-binding protein antibody; Interstitial retinol binding protein antibody; Interstitial retinol-binding protein antibody; IRBP antibody; RBP 3 antibody; rbp3 antibody; RBPI antibody; RET3_HUMAN antibody; Retinol binding protein 3 antibody; Retinol binding protein 3 interstitial antibody; Retinol-binding protein 3 antibody; RP66 antibody
Target Names
RBP3
Uniprot No.
Target Background
Function
IRBP (Interphotoreceptor Retinoid-Binding Protein) plays a crucial role in the visual cycle by transporting 11-cis and all-trans retinoids between the retinol isomerase in the retinal pigment epithelium and the visual pigments within the photoreceptor cells of the retina.
Gene References Into Functions
- This report is the first to document retinal dystrophy in children caused by homozygous nonsense RBP3 mutations, highlighting the essential role of IRBP in normal eye development and visual function. PMID: 25766589
- CMPK1 and RBP3 are associated with corneal curvature in Asian populations. PMID: 24963161
- Our research revealed that most patients with macular telangiectasia-2 possess retinal autoantibodies, with the most prevalent being directed against AGL, RBP3, and CK-B. PMID: 23882694
- Secretory defect and cytotoxicity are potential disease mechanisms for the retinitis pigmentosa (RP)-associated interphotoreceptor retinoid-binding protein (IRBP). PMID: 23486466
- The mouse retina facilitates cone dark adaptation eightfold faster than the retinal pigment epithelium. However, complete cone recovery requires both visual cycles. PMID: 21613504
- Reduced production of IRBP is an early event in the human diabetic retina and is linked to retinal neurodegeneration. PMID: 19823802
- Studies suggest that IRBP and S-Ag can initiate innate and, in susceptible individuals, adaptive immune response by attracting iDCs and T and B cells expressing CXCR3 and CXCR5 PMID: 15713799
- Analysis of IRBP proteolysis serves as a useful biomarker for uveitis PMID: 18266969
- Mutations in RBP3 are an infrequent cause of autosomal recessive retinitis pigmentosa. PMID: 19074801
- In interphotoreceptor retinoid-binding protein transgenic mice, cone dysfunction appears to stem from abnormal trafficking of cone opsins due to impaired delivery of all-transretinaldehyde chromophore in the absence of IRBP. PMID: 19193895
Database Links
Involvement In Disease
Retinitis pigmentosa 66 (RP66)
Protein Families
Peptidase S41A family
Subcellular Location
Secreted, extracellular space, extracellular matrix, interphotoreceptor matrix. Note=Interphotoreceptor matrix that permeates the space between the retina and the contiguous layer of pigment epithelium cells.
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