RD19A Antibody

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Description

Key Observations from Search Results

The term "RD19" appears exclusively in the context of plant biology research ( ). Specifically:

  • RD19 (RESPONSIVE TO DEHYDRATION19) is an Arabidopsis thaliana cysteine protease critical for RRS1-R–mediated resistance against the bacterial pathogen Ralstonia solanacearum.

  • It interacts with the bacterial effector PopP2, relocalizing to the nucleus to activate immune responses ( ).

  • No studies mention an "RD19A" variant or associated antibodies.

The remaining sources ( ) focus on CD19, a B cell surface protein targeted in immunology and cancer therapy:

  • Anti-CD19 antibodies (e.g., LY3541860 , clone 136.20.1 , and MAB7489R ) are well-characterized tools for modulating B cell function or detecting CD19 in research/clinical settings.

  • CD19 antibodies are unrelated to the plant protein RD19.

Potential Explanations for Discrepancy

  • Terminology Error: "RD19A" may be a typographical error conflating RD19 (plant protease) with CD19 (human/murine B cell marker).

  • Nomenclature Gap: RD19A could represent an uncharacterized isoform or a newly proposed target not yet documented in peer-reviewed literature.

Recommendations for Further Inquiry

If the query intends to reference CD19 antibodies, the following data from the sources may be relevant:

Table 1: Key Anti-CD19 Antibodies and Applications

Antibody NameTarget SpeciesClone/IDApplication(s)Source
LY3541860HumanOptimized IgG4B cell inhibition in autoimmune models
MAB7489RRat771404RImmunohistochemistry (IHC), flow cytometry
Clone 136.20.1HumanFMC63-derivedDetection of CD19-specific CAR T cells

Table 2: Functional Insights into CD19

  • Role in Immunity: CD19 regulates B cell receptor signaling, TLR9 responses, and humoral immunity ( ).

  • Therapeutic Targeting: Anti-CD19 antibodies are used to treat B cell malignancies and autoimmune diseases ( ).

Product Specs

Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
RD19A antibody; At4g39090 antibody; F19H22.190 antibody; Cysteine protease RD19A antibody; EC 3.4.22.- antibody; Protein RESPONSIVE TO DEHYDRATION 19 antibody; RD19 antibody
Target Names
RD19A
Uniprot No.

Target Background

Function
RD19A is a probable thiol protease that plays a critical role in plant defense mechanisms. It is essential for RRS1-mediated resistance against the bacterial pathogen *Ralstonia solanacearum*. RD19A acts as a host factor in the activation of RRS1-mediated resistance triggered by the bacterial effector PopP2. RD19A interacts with PopP2 to form a nuclear complex, which is necessary for initiating the resistance response.
Gene References Into Functions
  1. Research suggests that RD19A forms a nuclear complex with PopP2, a critical step in activating the RRS1-mediated resistance response. PMID: 18708476
Database Links

KEGG: ath:AT4G39090

STRING: 3702.AT4G39090.1

UniGene: At.2850

Protein Families
Peptidase C1 family
Subcellular Location
Lytic vacuole. Nucleus.

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