Recombinant Acanthamoeba polyphaga mimivirus Uncharacterized protein R610 (MIMI_R610)
Description
Overview
Recombinant Acanthamoeba polyphaga mimivirus Uncharacterized protein R610 (MIMI_R610) refers to a protein derived from the Acanthamoeba polyphaga Mimivirus, identified as MIMI_R610, and produced via recombinant DNA technology . Mimiviruses are giant viruses that infect Acanthamoeba species, which are opportunistic human pathogens . The MIMI_R610 protein is currently categorized as an uncharacterized protein, meaning its precise function and role within the virus's life cycle are not yet fully understood .
Background on Mimivirus
Acanthamoeba polyphaga Mimivirus is a large, complex virus first reported in 2003 . Its genome contains genes encoding nearly 1,000 proteins, including enzymes involved in the biosynthesis of unique sugars such as 4-amino-4,6-dideoxy-d-glucose (d-viosamine) . Mimiviruses have a significant impact on the host cell's processes, and a large part of the duplicated mimivirus gene families are likely to interfere with important host cell processes, such as transcription control .
Production and Availability
Recombinant MIMI_R610 protein is produced in yeast using recombinant technology . This allows for the production of high-purity protein suitable for research purposes .
Research Significance
Because MIMI_R610 is an uncharacterized protein, it represents an area of potential discovery in virology. Investigating this protein could reveal novel insights into viral mechanisms, host-virus interactions, and potential therapeutic targets . Understanding the functions of currently uncharacterized proteins like MIMI_R610 is crucial for a more complete understanding of Mimivirus biology and its interactions with its host .
Mimivirus and Autoimmunity
Research indicates that exposure to Mimivirus collagens can trigger autoimmunity . Mimivirus encodes collagen-like proteins, and exposure to these proteins can elicit the production of anti-collagen antibodies. These antibodies can target mouse collagen type II and are accompanied by T-cell reactivity to collagen and joint inflammation, similar to what is observed in collagen-induced arthritis .
A study showed that 30% of healthy human subjects and 36% of rheumatoid arthritis patients had antibodies recognizing the major Mimivirus capsid protein L425 . Furthermore, 6% of healthy subjects and 22% of rheumatoid arthritis patients had antibodies against the Mimivirus collagen protein L71 .
Tables
Product Specs
Note: While we prioritize shipping the format currently in stock, please specify your format preference in order notes for customized fulfillment.
Note: All proteins are shipped with standard blue ice packs unless dry ice shipping is specifically requested and pre-arranged. Additional fees apply for dry ice shipping.
The specific tag type is finalized during production. If a particular tag is required, please inform us for preferential development.
Target Background
KEGG: vg:9925249
