Recombinant Anopheles gambiae Eukaryotic translation initiation factor 3 subunit H (AGAP009204)
Description
Introduction to Recombinant Anopheles gambiae Eukaryotic Translation Initiation Factor 3 Subunit H (AGAP009204)
Recombinant Anopheles gambiae Eukaryotic Translation Initiation Factor 3 Subunit H (AGAP009204) is a recombinant protein derived from the African malaria mosquito, Anopheles gambiae. This protein is part of the eukaryotic translation initiation factor 3 (eIF3) complex, which plays a crucial role in the initiation of protein synthesis by facilitating the assembly of the preinitiation complex and preventing premature binding of ribosomal subunits . The recombinant form of this protein is often used in research to study its functions and potential applications.
Function and Importance of eIF3 Subunit H
The eIF3 complex is essential for the regulation of protein synthesis, which is a critical process in cellular metabolism and growth. Subunit H, specifically, is involved in the regulation of translation initiation, although its precise role in Anopheles gambiae is less well-documented compared to its mammalian counterparts. In mammals, eIF3 subunits have been shown to influence cell proliferation and differentiation by modulating the translation of specific mRNAs .
Production and Availability
Recombinant AGAP009204 is available for research purposes, typically stored at -20°C to maintain stability . The availability of this recombinant protein facilitates studies on its biochemical properties and potential biological functions in Anopheles gambiae.
Future Directions
Future research on AGAP009204 could focus on elucidating its specific role in Anopheles gambiae biology, particularly how it influences mosquito development, resistance to insecticides, or vectorial capacity. Such studies could contribute to the development of novel strategies for malaria control by targeting critical biological pathways in the mosquito.
Product Specs
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Target Background
Eukaryotic translation initiation factor 3 subunit H (eIF-3H) is a component of the eukaryotic translation initiation factor 3 (eIF-3) complex. This complex plays a crucial role in protein synthesis, specifically targeting a specialized subset of mRNAs. In conjunction with other initiation factors, eIF-3 facilitates mRNA and methionyl-tRNAi binding to the 40S ribosome. The eIF-3 complex preferentially initiates translation of mRNAs involved in cell proliferation.
KEGG: aga:AgaP_AGAP009204
STRING: 7165.AGAP009204-PA
