Recombinant Apis mellifera Diuretic hormone class 2

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Cat. No.
BT48388
Source
Yeast
Synonyms
; Diuretic hormone class 2; Diuretic peptide; DP; GLDLGLSRGFSGSQAAKHLMGLAAANYAGGP-amide) [Cleaved into: Brain peptide GLDLGLSRGFSGSQAA; Brain peptide GLDLGLSRGFSGSQAAKH]
Purity
>85% (SDS-PAGE)
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Cat. No.
BT48388
Source
E.coli
Synonyms
; Diuretic hormone class 2; Diuretic peptide; DP; GLDLGLSRGFSGSQAAKHLMGLAAANYAGGP-amide) [Cleaved into: Brain peptide GLDLGLSRGFSGSQAA; Brain peptide GLDLGLSRGFSGSQAAKH]
Purity
>85% (SDS-PAGE)
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Cat. No.
BT48388
Source
E.coli
Synonyms
; Diuretic hormone class 2; Diuretic peptide; DP; GLDLGLSRGFSGSQAAKHLMGLAAANYAGGP-amide) [Cleaved into: Brain peptide GLDLGLSRGFSGSQAA; Brain peptide GLDLGLSRGFSGSQAAKH]
Purity
>85% (SDS-PAGE)
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Cat. No.
BT48388
Source
Baculovirus
Synonyms
; Diuretic hormone class 2; Diuretic peptide; DP; GLDLGLSRGFSGSQAAKHLMGLAAANYAGGP-amide) [Cleaved into: Brain peptide GLDLGLSRGFSGSQAA; Brain peptide GLDLGLSRGFSGSQAAKH]
Purity
>85% (SDS-PAGE)
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Cat. No.
BT48388
Source
Mammalian cell
Synonyms
; Diuretic hormone class 2; Diuretic peptide; DP; GLDLGLSRGFSGSQAAKHLMGLAAANYAGGP-amide) [Cleaved into: Brain peptide GLDLGLSRGFSGSQAA; Brain peptide GLDLGLSRGFSGSQAAKH]
Purity
>85% (SDS-PAGE)
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Description

Functional Role in Honeybee Physiology

DH2 is implicated in:

  • Osmoregulation: Modulates fluid secretion rates in Malpighian tubules, analogous to other insect diuretic hormones .

  • Stress Response: Likely involved in drought or nutrient-imbalance adaptations, though direct evidence in A. mellifera remains limited .

Comparative studies in Drosophila melanogaster suggest diuretic hormones like DH2 increase chloride conductance in renal tubules via calcium-dependent signaling, a mechanism conserved across insects .

Experimental Use

  • Binding Assays: To identify receptor interactions and downstream signaling pathways.

  • Physiological Studies: Investigating osmotic stress responses in honeybees.

Limitations

  • Structural Stability: The hydrophobic nature of DH2 necessitates glycerol stabilization, complicating long-term storage .

  • Species-Specificity: Functional data are extrapolated from non-Apis models (e.g., Drosophila), highlighting a gap in honeybee-specific studies .

Future Directions

  • Mechanistic Studies: Clarify DH2’s role in caste-specific behaviors (e.g., foraging vs. nursing) and interactions with other neuropeptides .

  • Ecological Implications: Assess DH2’s relevance in climate adaptability, given rising environmental stressors on pollinators .

Product Specs

Form
Lyophilized powder. We will ship the available format, but if you have special requirements, please note them when ordering and we will accommodate your request.
Lead Time
Delivery times vary by purchase method and location. Consult your local distributor for specific delivery information. All proteins are shipped with standard blue ice packs. For dry ice shipping, contact us in advance; additional fees apply.
Notes
Avoid repeated freeze-thaw cycles. Working aliquots can be stored at 4°C for up to one week.
Reconstitution
Briefly centrifuge the vial before opening. Reconstitute the protein in sterile deionized water to 0.1-1.0 mg/mL. Add 5-50% glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final glycerol concentration is 50%.
Shelf Life
Shelf life depends on storage conditions, buffer components, storage temperature, and protein stability. Liquid form: 6 months at -20°C/-80°C. Lyophilized form: 12 months at -20°C/-80°C.
Storage Condition
Store at -20°C/-80°C upon receipt. Aliquot for multiple uses. Avoid repeated freeze-thaw cycles.
Tag Info
Tag type is determined during manufacturing. If you require a specific tag, please inform us and we will prioritize its development.
Synonyms
; Diuretic hormone class 2; Diuretic peptide; DP; GLDLGLSRGFSGSQAAKHLMGLAAANYAGGP-amide) [Cleaved into: Brain peptide GLDLGLSRGFSGSQAA; Brain peptide GLDLGLSRGFSGSQAAKH]
Buffer Before Lyophilization
Tris/PBS-based buffer, 6% Trehalose.
Datasheet
Please contact us to get it.
Expression Region
1-31
Protein Length
Cytoplasmic domain
Purity
>85% (SDS-PAGE)
Species
Apis mellifera (Honeybee)
Target Protein Sequence
GLDLGLSRGF SGSQAAKHLM GLAAANYAGG P
Uniprot No.
P85830

Target Background

Function
Regulates fluid secretion. Stimulates primary urine secretion in Malpighian tubules and dose-dependently increases cAMP levels in the tubules. Has a non-selective effect on Na+/K+ ion transport. In vitro, it primarily elevates intracellular Ca2+.
Database Links

STRING: 7460.GB17064-PA

Protein Families
Diuretic hormone class 2 family
Subcellular Location
Secreted.

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