Recombinant Arbacia lixula NADH-ubiquinone oxidoreductase chain 1 (ND1)
Description
Introduction to NADH-Ubiquinone Oxidoreductase Chain 1 (ND1)
NADH-ubiquinone oxidoreductase chain 1 (ND1) is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase, also known as Complex I. This enzyme plays a crucial role in the electron transport chain, facilitating the transfer of electrons from NADH to coenzyme Q10 (CoQ10) and translocating protons across the inner mitochondrial membrane, which helps generate ATP . While specific information on "Recombinant Arbacia lixula NADH-ubiquinone oxidoreductase chain 1 (ND1)" is limited, understanding the general function and structure of ND1 can provide insights into its potential recombinant form.
Function of NADH-Ubiquinone Oxidoreductase Chain 1 (ND1)
ND1 is part of Complex I, which is the first enzyme in the mitochondrial electron transport chain. It catalyzes the reaction:
This process involves the transfer of electrons from NADH to CoQ10, resulting in the translocation of four protons across the mitochondrial membrane, contributing to the proton gradient necessary for ATP synthesis .
Structure and Mechanism
Complex I, including the ND1 subunit, consists of a hydrophilic domain where redox reactions occur and a hydrophobic domain involved in proton translocation. The electron transfer pathway involves flavin mononucleotide (FMN) and a series of iron-sulfur clusters, culminating in the reduction of CoQ10 to ubiquinol .
Potential of Recombinant ND1 from Arbacia lixula
While there is no specific literature on "Recombinant Arbacia lixula NADH-ubiquinone oxidoreductase chain 1 (ND1)", research on peptides from Arbacia lixula suggests potential applications in biotechnology and medicine. For instance, peptides from A. lixula have been explored for anti-aging and anticancer properties . The concept of recombinant ND1 could involve using genetic engineering to express this protein in a system that allows for its study or application in bioenergetic research or therapeutic development.
Research Findings and Potential Applications
Given the lack of direct information on recombinant ND1 from Arbacia lixula, potential applications would likely align with those of Complex I in general, such as understanding mitochondrial function and dysfunction in diseases. Research on Complex I has highlighted its role in neurodegenerative diseases and metabolic disorders .
Table: Potential Applications of Recombinant ND1
| Application Area | Description |
|---|---|
| Mitochondrial Research | Studying mitochondrial function and dysfunction in diseases. |
| Therapeutic Development | Potential use in developing treatments for neurodegenerative diseases and metabolic disorders. |
| Biotechnology | Expression systems for studying protein structure and function. |
Product Specs
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Target Background
Recombinant Arbacia lixula NADH-ubiquinone oxidoreductase chain 1 (ND1): A core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). It is considered part of the minimal assembly necessary for catalytic activity. Complex I facilitates electron transfer from NADH to the respiratory chain, with ubiquinone believed to be its immediate electron acceptor.
