Recombinant Arthrobacter chlorophenolicus Undecaprenyl-diphosphatase (uppP)
Description
Key Definitions
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Undecaprenyl-diphosphatase (UppP): A membrane-associated enzyme that hydrolyzes undecaprenyl pyrophosphate (C55-PP) to undecaprenyl phosphate (C55-P), a critical step in bacterial cell wall synthesis and lipid II recycling .
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Arthrobacter chlorophenolicus: A Gram-positive bacterium renowned for degrading 4-chlorophenol via a hydroxyquinol pathway, mediated by the cph gene cluster .
UppP in Other Bacterial Species
While Arthrobacter chlorophenolicus has not been directly linked to UppP, its role in other bacteria is well-documented.
Arthrobacter chlorophenolicus: Focus on 4-Chlorophenol Degradation
The species is best known for its cph gene cluster, which mediates 4-chlorophenol degradation via hydroxyquinol. No evidence links Arthrobacter chlorophenolicus to UppP or its recombinant production.
Relevant Research on Arthrobacter chlorophenolicus
Potential Explanations for the Absence of Recombinant Arthrobacter UppP
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Misattribution of Species: UppP research in Bacillus or E. coli may have been conflated with Arthrobacter’s unrelated catabolic pathways.
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Lack of Functional Need: Arthrobacter chlorophenolicus may rely on alternative phosphatases (e.g., DgkA) for lipid II recycling, reducing evolutionary pressure to retain UppP.
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Uncharacterized Genomes: While Arthrobacter genomes lack annotated UppP homologs, genomic data for A. chlorophenolicus A6 remain limited .
Product Specs
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Generally, the shelf life of liquid protein is 6 months at -20°C/-80°C. The shelf life of lyophilized protein is 12 months at -20°C/-80°C.
Target Background
KEGG: ach:Achl_1910
STRING: 452863.Achl_1910
