Recombinant Aspergillus clavatus DNA mismatch repair protein msh3 (msh3), partial
Shipped with Ice Packs 
In Stock 
Product Specs
Form
Lyophilized powder. We will preferentially ship the available format. If you have special format requirements, please note them when ordering.
Lead Time
Delivery time varies by purchase method and location. Consult local distributors for specific delivery times. All proteins are shipped with normal blue ice packs by default. For dry ice shipment, contact us in advance; extra fees apply.
Notes
Avoid repeated freezing and thawing. Store working aliquots at 4°C for up to one week.
Reconstitution
Briefly centrifuge the vial before opening. Reconstitute protein in sterile deionized water to 0.1-1.0 mg/mL. Add 5-50% glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final glycerol concentration is 50%.
Shelf Life
Shelf life depends on storage conditions, buffer ingredients, temperature, and protein stability. Liquid form: 6 months at -20°C/-80°C. Lyophilized form: 12 months at -20°C/-80°C.
Storage Condition
Store at -20°C/-80°C upon receipt. Aliquot for multiple uses. Avoid repeated freeze-thaw cycles.
Tag Info
Tag type is determined during manufacturing. If you have a specific tag type requirement, please inform us, and we will prioritize its development.
Synonyms
msh3; ACLA_006180; DNA mismatch repair protein msh3; MutS protein homolog 3
Buffer Before Lyophilization
Tris/PBS-based buffer, 6%
Trehalose.
Datasheet
Please contact us to get it.
Protein Length
Partial
Purity
>85% (SDS-PAGE)
Species
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Target Names
Uniprot No.
Target Background
Function
Part of the post-replicative DNA mismatch repair system (MMR). Forms MutS beta by heterodimerizing with msh2. MutS beta binds to DNA mismatches, initiating repair. Msh3 provides substrate binding and specificity. MutS beta bends the DNA helix and shields ~20 base pairs. Primarily repairs insertion-deletion loops (IDLs) of 2-13 nucleotides, but also repairs base-base and single insertion-deletion mismatches. Forms a ternary complex with MutL alpha after mismatch binding, directing downstream MMR events (strand discrimination, excision, and resynthesis). ATP binding and hydrolysis are crucial for mismatch repair.
Database Links
KEGG: act:ACLA_006180
STRING: 5057.CADACLAP00000673
Protein Families
DNA mismatch repair MutS family, MSH3 subfamily
Subcellular Location
Nucleus.
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