Recombinant Bartonella quintana Phosphoglucosamine mutase (glmM)
Description
Definition and Functional Role
Phosphoglucosamine mutase (GlmM) catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate, a critical step in the biosynthesis of peptidoglycan and lipid A moieties in bacterial cell walls . In Bartonella quintana, this enzyme is likely essential for maintaining structural integrity and pathogenicity, as observed in E. coli and other gram-negative bacteria .
Key Functions:
-
Peptidoglycan Synthesis: Required for polymerizing UDP-N-acetylglucosamine, a precursor for cell wall assembly .
-
Lipid A Biosynthesis: Supports lipopolysaccharide (LPS) production, which is vital for B. quintana survival in human hosts .
Biochemical Properties and Regulatory Mechanisms
Autophosphorylation: In E. coli, GlmM requires phosphorylation via ATP for activity, with Serine 102 as the critical residue . This post-translational modification may be conserved in B. quintana, though experimental validation is lacking.
Enzyme Kinetics:
Research Gaps and Potential Applications
Table 1: GlmM Homologs in Pathogenic Bacteria
Product Specs
Note: While we prioritize shipping the format currently in stock, please specify your format preference in order notes for customized fulfillment.
Note: All proteins are shipped with standard blue ice packs unless dry ice shipping is specifically requested and agreed upon in advance. Additional fees apply for dry ice shipping.
Generally, the shelf life is 6 months at -20°C/-80°C for liquid formulations and 12 months at -20°C/-80°C for lyophilized formulations.
The tag type will be determined during production. If you require a specific tag, please inform us, and we will prioritize its development.
Target Background
KEGG: bqu:BQ11740
STRING: 283165.BQ11740
