Recombinant Bovine Leucine-rich repeat-containing protein 3B (LRRC3B)
Description
Introduction
Leucine-rich repeat-containing protein 3B (LRRC3B) is a protein encoded by the LRRC3B gene, and it has been identified as a tumor suppressor gene potentially involved in carcinogenesis . LRRC3B contains leucine-rich repeats, which are known to participate in protein-protein interactions . Studies suggest that variations in the LRRC3B gene may contribute to the development and progression of certain cancers, such as breast cancer .
Gene Structure and Polymorphisms
The LRRC3B gene exhibits several single nucleotide polymorphisms (SNPs), which are variations in a single nucleotide within the gene sequence. These SNPs can influence the risk of developing certain diseases. For instance, research has explored the association between LRRC3B SNPs and breast cancer (BC) .
Specific LRRC3B polymorphisms, such as rs6551122 and rs12635768, have been linked to smaller breast cancer tumor sizes. Other variants, including rs112276562, rs6551122, and rs73150416, have been associated with a lower incidence of progesterone receptor (PR)-positive breast cancer . The rs6788033 polymorphism is correlated with lower expression levels of Ki-67, a marker of cell proliferation, in breast cancer .
Table 1: Association between LRRC3B Polymorphisms and Clinical Features of Breast Cancer
| Polymorphism | Clinical Feature | Odds Ratio (OR) | p-value |
|---|---|---|---|
| rs6551122 | Smaller tumor size (<2cm) | 0.51 | 0.028 |
| rs12635768 | Smaller tumor size (<2cm) | 0.36 | 0.023 |
| rs112276562 | Lower incidence of PR+ BC | 0.56 | 0.002 |
| rs73150416 | Lower incidence of PR+ BC | 0.57 | 0.005 |
| rs6788033 | Lower Ki-67 expression | 0.64 | 0.030 |
Role in Breast Cancer
Multiple studies suggest that LRRC3B SNPs contribute to breast cancer risk, suggesting that LRRC3B variants might help predict BC progression . A study showed that the 'GATT' haplotype in Block 2 had a higher risk for BC (OR = 1.29, 95% CI: 1.00–1.65, p = 0.048) .
Table 2: False-Positive Report Probability (FPRP) Values for Associations between LRRC3B Polymorphisms and Breast Cancer Susceptibility
| Polymorphism | Genetic Model | FPRP Value |
|---|---|---|
| rs1907168 | Heterozygote | 0.184 |
| rs112276562 | Heterozygote | 0.095 |
| rs73150416 | Heterozygote | 0.159 |
| rs73150416 | Dominant | 0.189 |
LRRC3B as a Predictor of Immunotherapy Response
DNA hypomethylation of LRRC3B could be used to predict anti-PD-1 treatment outcomes in NSCLC and BRCA .
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