Recombinant Bovine Motile sperm domain-containing protein 1 (MOSPD1)
Description
Functions and Mechanisms of MOSPD1
MOSPD1 is known to be involved in the regulation of transcription by RNA polymerase II, with roles in both negative and positive regulation . In the context of colorectal cancer, MOSPD1 is upregulated by the Wnt/β-catenin signaling pathway, which plays a crucial role in cancer development and progression . This upregulation is mediated through enhancer elements in the 3'-flanking region of the MOSPD1 gene, interacting with transcription factors like TCF7L2 and β-catenin .
Colorectal Cancer
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Expression Levels: MOSPD1 expression is significantly higher in colorectal cancer tissues compared to non-tumor tissues, with a 2.18-fold increase .
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Correlation with Wnt Targets: MOSPD1 expression correlates positively with known Wnt target genes such as RNF43, AXIN2, and MYC .
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Mechanism: The Wnt/β-catenin pathway regulates MOSPD1 through specific enhancer elements in its 3'-flanking region .
Mesenchymal Stem Cells
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Proliferation and Differentiation: Cells deficient in MOSPD1 show defects in mesenchymal stem cell proliferation and differentiation, indicating a role for MOSPD1 in these processes .
Early Embryos
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Marker for Development: MOSPD1 is identified as a putative marker for early-stage human embryos, specifically at the 3-day, 8-cell stage .
Potential Applications and Future Directions
While specific studies on "Recombinant Bovine Motile sperm domain-containing protein 1 (MOSPD1)" are not available, understanding its human counterpart provides a foundation for exploring its potential applications in biotechnology and veterinary medicine. Recombinant proteins are often used for research, diagnostics, and therapeutic purposes, and MOSPD1 could potentially be used in similar contexts if its bovine form is developed and studied.
Data Tables
Given the lack of specific data on "Recombinant Bovine Motile sperm domain-containing protein 1 (MOSPD1)", we can summarize some key findings related to human MOSPD1:
Product Specs
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Target Background
Recombinant Bovine Motile sperm domain-containing protein 1 (MOSPD1) plays a role in mesenchymal stem cell differentiation and/or proliferation. It has been proposed to be involved in epithelial-to-mesenchymal transition (EMT). However, further research suggests that its role in EMT or stem cell self-renewal may be limited to later stages of differentiation, rather than being essential for these processes.
