Recombinant Bovine Mpv17-like protein 2 (MPV17L2)
Description
Overview and Definition
Recombinant Bovine MPV17L2 refers to a truncated form of the mitochondrial protein MPV17L2 (MPV17 mitochondrial membrane protein-like 2), expressed in mammalian cell systems. This recombinant protein is engineered for research purposes, enabling functional studies of its role in mitochondrial biology. MPV17L2 is a 206-amino-acid transmembrane protein localized to the inner mitochondrial membrane (IMM), where it interacts with mitochondrial ribosomal components and nucleic acids .
Research Findings and Functional Insights
MPV17L2 is critical for mitochondrial ribosome assembly and mtDNA organization. Key findings include:
Ribosomal Biogenesis
Mitochondrial DNA Dynamics
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mtDNA Aggregation: MPV17L2 depletion induces nucleoid enlargement and mtDNA clustering, independent of mtDNA depletion .
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mtRNA Stability: Reduced MPV17L2 expression impairs mitochondrial translation, as evidenced by diminished monosome levels and impaired protein synthesis .
Pathway Involvement and Biological Relevance
MPV17L2 is linked to the Peroxisome pathway, though its primary role is mitochondrial. Related pathway components include:
MPV17L2’s inclusion in this pathway may reflect indirect regulatory interactions, though its core function resides in mitochondrial ribosome assembly .
Applications and Research Implications
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Mitochondrial Disease Modeling: MPV17L2 knockdown mimics ribosomal defects seen in mitochondrial disorders, enabling studies of ribosome-nucleoid interactions .
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Therapeutic Targeting: Insights into MPV17L2’s role in translation may inform strategies for mtDNA depletion syndromes, though direct therapeutic applications remain speculative.
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Structural Studies: The recombinant protein facilitates biochemical assays (e.g., co-sedimentation, immunoprecipitation) to map ribosomal interactions .
Product Specs
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Note: All proteins are shipped with standard blue ice packs. Dry ice shipping requires advance notification and incurs additional charges.
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