Recombinant Bovine Potassium voltage-gated channel subfamily D member 1 (KCND1)
Description
Overview of Human KCND1
KCND1 encodes the α-subunit of Kv4.1, a voltage-gated potassium channel critical for rapidly inactivating A-type currents in neurons and cardiac cells . It modulates action potential repolarization and neuronal excitability .
Key Properties of Recombinant Human KCND1:
Research Findings on Human KCND1
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Pathogenic Variants: Hemizygous KCND1 variants are linked to X-linked neurodevelopmental disorders with neuropsychiatric features and epilepsy .
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Channel Dynamics: KCND1’s biophysical properties are modulated by auxiliary β-subunits (e.g., KChIP2b, DPP6) .
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Disease Associations:
Functional Characterization
KCND1 variants alter channel inactivation kinetics and voltage dependence when expressed in Xenopus laevis oocytes . For example:
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p.Arg328Cys: Slowed inactivation and hyperpolarizing shift in voltage dependence .
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p.Arg419Trp: Reduced current density and accelerated recovery from inactivation .
Limitations and Recommendations
The query’s focus on bovine KCND1 cannot be addressed with current data. To proceed:
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Verify if the intended target is human KCND1 (well-characterized).
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Explore bovine genome databases for KCND1 homologs, as none are documented in the provided sources.
Product Specs
Note: We prioritize shipping the format currently in stock. However, if you have specific format requirements, please indicate them during order placement, and we will accommodate your request.
Note: All proteins are shipped with standard blue ice packs. If you require dry ice shipping, please inform us in advance as additional fees will apply.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
