Recombinant Brucella abortus biovar 1 Protein FdhD homolog (fdhD)
Description
Introduction to Recombinant Brucella abortus biovar 1 Protein FdhD Homolog (fdhD)
The Recombinant Brucella abortus biovar 1 Protein FdhD homolog (fdhD) is a genetically engineered protein derived from the Brucella abortus bacterium, specifically from its biovar 1. Brucella abortus is a pathogen responsible for bovine brucellosis, a zoonotic disease affecting cattle and potentially humans. The fdhD protein is a homolog of formate dehydrogenase, which plays a role in the metabolic processes of bacteria. Recombinant proteins like fdhD are produced through biotechnological methods, often for research or vaccine development purposes.
Background on Brucella abortus and Its Proteins
Brucella abortus is a Gram-negative bacterium that causes brucellosis in cattle. It is known for its ability to infect and replicate within host cells, making it a challenging pathogen to combat. The bacterium's cell wall contains several proteins that are of interest for vaccine development and diagnostic tools. These include outer membrane proteins (Omps) like Omp25, Omp31, and Omp2b, which have been studied for their immunogenic properties .
Recombinant Protein Production
Recombinant proteins are produced by inserting the gene encoding the protein of interest into a suitable expression system, such as bacteria or yeast. The fdhD homolog from Brucella abortus biovar 1 would be expressed in a host organism, purified, and then used for various applications, including research into its potential as a vaccine component or diagnostic antigen.
Research Findings and Applications
While specific research findings on the Recombinant Brucella abortus biovar 1 Protein FdhD homolog (fdhD) are not widely available, studies on other Brucella proteins have shown promise in vaccine development and diagnostics. For example, proteins like nucleoside diphosphate kinase (Ndk) have been evaluated for their protective effects against Brucella infections . Similarly, recombinant vaccines based on other Brucella proteins have demonstrated enhanced immune responses and protection in animal models .
Potential Applications in Vaccine Development
Recombinant proteins can serve as subunit vaccines, offering a safer alternative to live attenuated vaccines. They can induce specific immune responses without the risk of reversion to virulence. The fdhD homolog, if found to be immunogenic, could potentially be used in combination with other antigens to enhance vaccine efficacy.
Data Table: Overview of Brucella abortus Proteins and Their Applications
| Protein | Function/Role | Application/Interest |
|---|---|---|
| Omp25, Omp31 | Outer membrane proteins | Vaccine development, diagnostics |
| Ndk | Nucleoside diphosphate kinase | Vaccine component, protective effects |
| FdhD homolog | Formate dehydrogenase homolog | Potential vaccine component, research |
| LLO, BAX, SMAC | Apoptotic proteins | Enhanced vaccine efficacy |
Product Specs
Note: While we prioritize shipping the format currently in stock, please specify your format preference in order notes for customized preparation.
Note: Our proteins are shipped with standard blue ice packs. Dry ice shipping requires advance notice and incurs additional charges.
The tag type is determined during the production process. If you require a specific tag, please inform us, and we will prioritize its development.
Target Background
KEGG: bmb:BruAb2_0534
