Recombinant Candida albicans Assembly factor CBP4 (CBP4)
Description
Role of CBP4 in Mitochondrial Function
CBP4 is involved in the assembly of mitochondrial respiratory complexes, which are crucial for energy production in C. albicans. Mitochondrial function is essential for the survival and virulence of C. albicans, as it affects various cellular processes, including metabolism and stress response.
| Protein | Role in Mitochondrial Function | Impact on C. albicans |
|---|---|---|
| CBP4 | Assembly factor for mitochondrial complexes | Essential for energy production and cellular stress response |
| COX11 | Uncharacterized protein involved in cytochrome c oxidase assembly | Contributes to mitochondrial respiratory chain assembly |
| COX15 | Involved in cytochrome c oxidase assembly | Important for mitochondrial function and energy metabolism |
Research Findings on CBP4
While specific studies on recombinant CBP4 are scarce, research on mitochondrial assembly factors in C. albicans suggests that these proteins play critical roles in maintaining mitochondrial integrity and function. For instance, studies on antifungal agents like SM21 have shown that mitochondrial damage can lead to resistance mechanisms in C. albicans, highlighting the importance of mitochondrial function in fungal survival .
Potential Applications of CBP4 Research
Understanding the role of CBP4 and other mitochondrial assembly factors could lead to the development of novel antifungal strategies. Targeting mitochondrial function could provide a new avenue for combating C. albicans infections, especially in cases where traditional antifungals are ineffective due to resistance.
References
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Frontiers in Cellular and Infection Microbiology: Recent Advances and Opportunities in the Study of Candida albicans.
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PMC: Genomic Profiling of the Response of Candida albicans to Antifungal Agents.
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PMC: Antifungal Agent 4-AN Changes the Genome-Wide Expression Profile, Downregulates Virulence-Associated Genes and Induces Necrosis in Candida albicans Cells.
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PMC: Use of Haploid Model of Candida albicans to Uncover Mechanism of Antifungal Drug Resistance.
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PLOS Genetics: A Human-Curated Annotation of the Candida albicans Genome.
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PMC: Enhancing Antifungal Drug Discovery Through Co-Culture with Antarctic Streptomyces albidoflavus Strain CBMAI 1855.
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PLOS Pathogens: Genome-Wide Fitness Test and Mechanism-of-Action Studies of Candida albicans.
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Candida Genome Database: A resource for genomic sequence data and gene and protein information for Candida albicans and related species.
Product Specs
Note: While we prioritize shipping the format currently in stock, please specify your preferred format in order notes for fulfillment.
Note: Standard shipping includes blue ice packs. Dry ice shipping requires prior arrangement and incurs additional charges.
The tag type is determined during production. If you require a specific tag, please inform us, and we will prioritize its development.
Target Background
KEGG: cal:CAALFM_C108470WA
