Recombinant Chicken Transmembrane protein 231 (TMEM231)
Description
Introduction to Recombinant Chicken Transmembrane Protein 231 (TMEM231)
Recombinant Chicken Transmembrane Protein 231 (TMEM231) is a protein produced through recombinant DNA technology, where the gene encoding TMEM231 is inserted into a host organism such as yeast, E. coli, or mammalian cells. This allows for the large-scale production of the protein for research and potential therapeutic applications. TMEM231 is a critical component of the transition zone in primary cilia, playing a crucial role in maintaining ciliary structure and function .
Production and Sources of Recombinant Chicken TMEM231
Recombinant Chicken TMEM231 is available in various forms, depending on the host organism used for its production:
Biological Function of TMEM231
TMEM231 is essential for the formation and function of the transition zone in primary cilia. It interacts with other components of the Meckel syndrome (MKS) complex, such as B9d1 and Mks1, to regulate the localization of ciliary membrane proteins . Mutations in the TMEM231 gene have been associated with ciliopathies like Meckel syndrome and orofaciodigital syndrome type 3 .
Research Findings and Applications
Research on TMEM231 has primarily focused on its role in ciliopathies. Studies have shown that mutations in TMEM231 disrupt ciliary function, leading to developmental abnormalities such as polydactyly and kidney cysts . The recombinant protein can be used in studies to understand the molecular mechanisms underlying these conditions and to explore potential therapeutic strategies.
Product Specs
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