Recombinant Colobus guereza Serine/threonine-protein kinase 4 (STK4)
Shipped with Ice Packs 
In Stock 
Product Specs
Form
Lyophilized powder. We will preferentially ship the format we have in stock. If you have special format requirements, please note them when ordering.
Lead Time
Delivery times vary by purchase method and location. Consult local distributors for specific delivery times. Proteins are shipped with blue ice packs by default. For dry ice shipping, contact us in advance; extra fees apply.
Notes
Avoid repeated freeze-thaw cycles. Store working aliquots at 4°C for up to one week.
Reconstitution
Briefly centrifuge the vial before opening. Reconstitute protein in sterile deionized water to 0.1-1.0 mg/mL. Add 5-50% glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final glycerol concentration is 50%.
Shelf Life
Shelf life depends on storage conditions, buffer ingredients, temperature, and protein stability. Liquid form: 6 months at -20°C/-80°C. Lyophilized form: 12 months at -20°C/-80°C.
Storage Condition
Store at -20°C/-80°C upon receipt. Aliquot for multiple uses. Avoid repeated freeze-thaw cycles.
Tag Info
Tag type is determined during manufacturing. If you require a specific tag, please inform us, and we will prioritize its development.
Synonyms
STK4; Serine/threonine-protein kinase 4; EC 2.7.11.1) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit; MST1/N); Serine/threonine-protein kinase 4 18kDa subunit; MST1/C)]
Buffer Before Lyophilization
Tris/PBS-based buffer, 6%
Trehalose.
Datasheet
Please contact us to get it.
Expression Region
1-487
Protein Length
full length protein
Purity
>85% (SDS-PAGE)
Species
Colobus guereza (Mantled guereza) (Eastern black-and-white colobus monkey)
Target Names
Target Protein Sequence
METVQLRNPP RRQLKKLDED SLTKQPEEVF DVLEKLGEGS YGSVYKAIHK ETGQIVAIKQ
VPVESDLQEI IKEISIMQQC DSPHVVKYYG SYFKNTDLWI VMEYCGAGSV SDIIRLRNKT
LTEDEIATVL QSTLKGLEYL HFMRKIHRDI KAGNILLNTE GHAKLADFGV AGQLTDTMAK
RNTVIGTPFW MAPEVIQEIG YNCVADIWSL GITAIEMAEG KPPYADIHPM RAIFMIPTNP
PPTFRKPELW SDNFTDFVKQ CLVKSPEQRA TATQLLQHPF VKSAKGVSIL RDLINEAMDV
KLKRQESQQR EVDQDDEENS EEDEMDSGTM VRAVGDEMGT VRVASTMTDG ANTMIEHDDT
LPSQLGTMVI NTEDEEEEGT MKRRDETMQP AKPSFLEYFE QKEKENQINS FGKSVPGPLK
NSSDWKIPQD GDYEFLKSWT VEDLQKRLLA LDPMMEQEIE EIRQKYQSKR QPILDAIEAK
KRRQQNF
Uniprot No.
Target Background
Function
STK4 is a stress-activated, pro-apoptotic kinase. Upon caspase cleavage, it enters the nucleus, causing chromatin condensation and DNA fragmentation. It is a key component of the Hippo pathway, regulating organ size and tumor suppression by controlling cell proliferation and apoptosis. STK4/MST1, with SAV1, phosphorylates and activates LATS1/2 (complexed with MOB1), which inactivates YAP1 and WWTR1/TAZ. YAP1 phosphorylation prevents nuclear translocation and regulation of genes involved in cell proliferation, death, and migration. STK3/MST2 and STK4/MST1 suppress hepatocyte proliferation, prevent oval cell activation, and inhibit tumor formation. STK4 phosphorylates histone H2B Ser14 during apoptosis, FOXO3 (inducing nuclear translocation and cell death), MOBKL1A, MOBKL1B, RASSF2, TNNI3, FOXO1 (Ser212, activating it and stimulating PMAIP1 transcription), and SIRT1 (inhibiting p53 deacetylation, promoting p53-dependent transcription and apoptosis). It inhibits AKT1 and phosphorylates AR (Ser650), suppressing its activity.
Protein Families
Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
Subcellular Location
Cytoplasm. Nucleus.
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