Recombinant Danio rerio DDB1- and CUL4-associated factor 17 (dcaf17)
Description
Functional and Biological Significance
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Role in Ubiquitination: Dcaf17 acts as a substrate receptor in the CRL4 ubiquitin ligase complex, targeting specific proteins for proteasomal degradation .
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Reproductive Biology: Knockout studies in mice revealed that Dcaf17 deletion causes male infertility due to impaired spermatogenesis, including abnormal acrosome formation and nuclear compaction .
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Disease Associations: Orthologs in humans (DCAF17) are linked to Woodhouse-Sakati syndrome, a rare genetic disorder characterized by hypogonadism and neurological defects .
Research Applications
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Protein-Protein Interaction Studies: Used to investigate CRL4 complex dynamics .
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Spermatogenesis Models: Zebrafish dcaf17 provides insights into conserved mechanisms of germ cell development .
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Disease Mechanism Analysis: Functional studies of dcaf17 mutations help elucidate molecular pathways in Woodhouse-Sakati syndrome .
Key Research Findings
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Knockout Phenotypes: Dcaf17⁻/⁻ mice exhibit vacuolated seminiferous tubules and non-motile sperm, highlighting its necessity for spermiogenesis .
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Conservation Across Species: Zebrafish dcaf17 shares structural homology with human and rodent variants, making it a viable model for translational studies .
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Therapeutic Potential: Targeting dcaf17 interactions could modulate ubiquitination pathways in diseases like cancer or genetic syndromes .
Technical Considerations
Product Specs
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