Recombinant Danio rerio Malectin (mlec)
Description
Production and Purification
Recombinant Danio rerio Malectin is likely produced using methods similar to human MLEC :
Glycoprotein quality control:
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Binds Glc₂Man₉GlcNAc₂ (G2M9) N-glycans on misfolded glycoproteins, retaining them in the ER for degradation .
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Interacts with ribophorins (OST complex subunits) to mediate ER-associated degradation (ERAD) .
Immune modulation:
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Bacterial binding: Malectin orthologs bind Gram-positive and Gram-negative bacteria via carbohydrate-binding modules (CBMs) .
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Antiviral activity: Overexpression reduces viral replication (e.g., VHSV in seahorse models) .
Disease relevance:
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Upregulated in hepatocellular carcinoma (HCC) and promotes tumorigenesis in humans .
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SNPs in MLEC correlate with cerebral palsy via macrophage polarization defects .
Research Tools for Danio rerio Malectin
Key Research Gaps
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Functional studies: No direct data on Danio rerio Malectin’s role in zebrafish immunity or development.
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Structural analysis: Crystal/NMR structures are unavailable for zebrafish malectin.
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Disease models: Role in zebrafish cancer or ER stress responses remains unexplored.
Future Directions
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CRISPR/Cas9 knockout models to assess developmental and immune phenotypes.
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Glycan microarray assays to map binding specificity.
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Comparative studies with human/seahorse malectin to identify conserved mechanisms.
Product Specs
Note: We will prioritize shipping the format currently in stock. However, if you have a specific format requirement, please indicate it in your order notes. We will prepare the product according to your request.
Note: All of our proteins are shipped with standard blue ice packs by default. If you require dry ice shipping, please inform us in advance as additional fees will apply.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
