Recombinant Danio rerio Protein cornichon homolog 2 (cnih2)
Description
General Information
Danio rerio Protein Cornichon Homolog 2 (Cnih2) is a protein that, in zebrafish, is ubiquitously expressed throughout the embryo from fertilization onward and accumulates at higher levels in cells of the telencephalon and the ventral hindbrain . Cnih2 belongs to a conserved protein family found in eukaryotes .
Structure and Function
Plant cornichon homologs have about 40% similarity to cornichons in yeast, flies, worms, zebra fish, and humans . The protein is predicted to have three membrane-spanning α-helixes, with the N-terminus towards the cytoplasm and the C-terminus located in the ER lumen . All plant cornichon homologs possess an acidic domain in the luminal C-terminus .
Cnih2 is an auxiliary subunit of the ionotropic glutamate receptor of the AMPA subtype . Cnih2 proteins participate in the selection of integral membrane proteins as cargo for their correct targeting . Cnih2 may act as a cargo receptor, located in the endoplasmic reticulum, interacting with other proteins for their delivery to the Golgi apparatus .
Expression and Localization
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Cnih2 is expressed in the brain, diencephalon, and tegmentum .
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In rice, cornichon homologues did not locate exclusively to one specific compartment but rather circulated actively between the Golgi and the ER, in association with COPII vesicles .
Research Findings
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In mouse models, Cnih2 conditional knockout mice exhibit reduced AMPA receptor synaptic transmission in the hippocampus .
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Significant upregulation of CNIH2 has been found to promote esophageal squamous cell carcinoma progression .
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The cargo receptor cornichon interacts with the low-affinity Na+ transporter OsHKT1;3 for its delivery to the Golgi apparatus .
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The interaction between OsHKT1;3 and OsCNIH1 occurs at the ER and is required to direct the Na+ transporter to the Golgi .
Table of Cnih2 Information
Product Specs
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