Recombinant Diadromus pulchellus idnoreovirus 1 Uncharacterized protein S3bis (S3bis), partial
Description
Genomic Context and Functional Hypotheses
DpIRV-1 belongs to the Idnoreovirus genus, characterized by a segmented double-stranded RNA (dsRNA) genome. Key genomic features include:
| Genome Segment | Length (kbp) | Protein | Proposed Function |
|---|---|---|---|
| Seg1–Seg10 | 4.8–0.98 | VP1–VP10 | Core components (e.g., RNA polymerase) |
| Extra Segment | 3.33 | – | Linked to host sex/ploidy determination |
The presence of an 11th dsRNA segment in DpIRV-1 is unique and may influence host biology, potentially affecting development or survival in Diadromus pulchellus . While S3bis is not explicitly mapped in available studies, its partial nature suggests it may correspond to a truncated version of a core viral protein (e.g., VP3 or VP5).
Research Gaps and Limitations
Critical uncertainties persist:
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Nomenclature Conflicts: S3bis is not directly referenced in primary literature; UniProt and commercial sources label similar proteins as S2 or S3, raising questions about naming consistency .
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Functional Role: No studies explicitly describe S3bis’s biological activity. Analogies to other idnoreoviruses (e.g., Operophtera brumata idnoreovirus) suggest potential roles in capsid assembly or replication .
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Host Interactions: DpIRV-1’s extra dsRNA segment may modulate Diadromus pulchellus biology, but S3bis’s role remains unexplored .
Potential Applications in Research
| Area | Application |
|---|---|
| Virology | Studying idnoreovirus replication mechanisms and host-virus co-evolution |
| Entomology | Investigating viral impacts on Diadromus pulchellus populations and pest control efficacy |
| Biotechnology | Exploring recombinant proteins for biocontrol or vaccine development |
Comparative Analysis with Related Proteins
The table below contrasts S3bis with DpIRV-1’s characterized proteins:
| Protein | UniProt ID | Molecular Weight | Proposed Role | Source |
|---|---|---|---|---|
| S3bis | – | Partial (unknown) | Hypothetical core/capsid | Recombinant (mammalian) |
| S2 (S3) | Q85444 | ~69 kDa | Uncharacterized | Recombinant (mammalian) |
| VP1 | – | 155.7 kDa | RNA polymerase | Native (ObIRV) |
Data for DpIRV-1’s proteins are inferred from Operophtera brumata idnoreovirus (ObIRV) due to limited sequencing .
Product Specs
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