Recombinant Dictyostelium discoideum Probable carboxypeptidase S-like 2 (DDB_G0267984)
Description
Introduction
Dictyostelium discoideum is a cellular slime mold recognized as a valuable model organism for studying developmental and cell biology due to its ease of use and simple life cycle . Recent studies suggest that Dictyostelium may serve as a source of novel lead compounds for pharmacological and medical research . One such compound is Recombinant Dictyostelium discoideum Probable carboxypeptidase S-like 2 (DDB_G0267984).
Overview of Dictyostelium discoideum as a Source of Drug Leads
Genome analyses reveal that D. discoideum has approximately 43 polyketide synthase genes . This suggests that Dictyostelium cellular slime molds produce an abundance of secondary metabolites that could be used as novel lead compounds for drug discovery .
Carboxypeptidases
Carboxypeptidases are enzymes that catalyze the hydrolysis of peptide bonds at the C-terminal end of proteins or peptides.
Tables for Data Presentation
Tables are used to organize data that is too detailed or complicated to be described adequately in the text, allowing the reader to quickly see the results . They can highlight trends or patterns in the data and make a manuscript more readable by removing numeric data from the text .
Table 1: How to Choose Between Tables, Figures, and Text to Present Data
| Use a Table | Use a Figure | Use Text |
|---|---|---|
| To show many and precise numerical values and other specific data in a small space | To show trends, patterns, and relationships across and between datasets | When you don't have extensive data to present |
| To compare and contrast data values with several shared characteristics or variables | To summarize research results | When putting your data into a table would mean creating a table with 2 or fewer columns |
| To show the presence or absence of specific characteristics | To present a visual explanation of a sequence of events, procedures, or characteristics | When the data that you are planning to present is irrelevant to the main study findings. |
Other Compounds Isolated from Dictyostelium
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Differentiation-Inducing Factors (DIFs): DIF-1, DIF-2, and DIF-3 are chlorinated alkylphenones that induce stalk-cell differentiation . DIF-1 is the most active, inducing stalk-cell differentiation in vitro at nanomolar levels .
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Dictyopyrones: Dictyopyrones A–D promote morphogenesis of D. discoideum, inhibit spore formation, and promote stalk-cell formation in vitro . They also suppress cell growth in human leukemia K562 cells in vitro .
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MPBD (4-methyl-5-n-pentylbenzene-1,3-diol): MPBD promotes stalk-cell and spore differentiation in D. discoideum under certain in vitro culture conditions . It also suppresses the growth of human leukemia K562 and HL-60 cells in vitro and possesses antimicrobial activities .
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Monochasiols: Monochasiols A–H are chlorinated alkylresorcinols isolated from the fruiting bodies of D. monochasioides . Monochasiol A suppresses ConA-induced IL-2 production in Jurkat T cells without affecting cell viability .
Product Specs
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Target Background
KEGG: ddi:DDB_G0267984
STRING: 44689.DDB0233064
