Recombinant Dictyostelium discoideum Putative lysophosphatidylcholine acyltransferase (taz)
Product Specs
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Target Background
This acyltransferase is crucial for remodeling newly synthesized cardiolipin (CL), a vital phospholipid in the mitochondrial inner membrane. It modifies CL's acyl chains with tissue-specific variations, essential for optimal mitochondrial function. CL acyl group remodeling impacts the assembly and stability of respiratory chain complex IV and its supercomplexes, highlighting CL's critical role in the co-assembly of lipids and proteins within mitochondrial membranes.
The enzyme catalyzes transacylation between phospholipids and lysophospholipids, exhibiting the highest activity between phosphatidylcholine (PC) and CL. It catalyzes both lysophosphatidylcholine (LPC) reacylation and PC-CL transacylation, exchanging acyl groups between CL and PC through bidirectional transacylations. While exhibiting lower activity, it also catalyzes transacylations between other phospholipids, including phosphatidylethanolamine (PE) and CL, PC and PE, and PC and phosphatidate (PA).
The enzyme is not regiospecific, transferring acyl groups to either the sn-1 or sn-2 positions of monolysocardiolipin (MLCL), ensuring uniform and symmetrical CL acyl distribution. It cannot transacylate dilysocardiolipin (DLCL), limiting MLCL's role to acyl acceptance. This CoA-independent enzyme reshuffles molecular species within a single phospholipid class, redistributing fatty acids between MLCL, CL, and other lipids, thus extending CL's half-life. Its reversible action allows for cyclical changes, such as membrane fission/fusion or bending/flattening. By influencing lipid composition flexibility, it significantly contributes to the dynamics of mitochondrial membranes.
KEGG: ddi:DDB_G0291922
STRING: 44689.DDB0237792
