Recombinant Gorilla gorilla gorilla C5a anaphylatoxin chemotactic receptor (C5AR1)
Description
Production and Validation
Recombinant Gorilla C5AR1 is produced using heterologous expression systems, with validated specifications:
Key validation data:
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Specificity: Reactivity confirmed via SDS-PAGE and Western blot using anti-His monoclonal antibodies
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Activity: Binds C5a with Kd values comparable to human C5AR1 (low nM range)
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Cross-reactivity: Recognized by antibodies raised against human C5AR1 due to high sequence homology
Disease Modeling
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Sepsis: C5AR1 blockade in murine models reduced mortality by enhancing pathogen clearance and preserving liver function .
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COVID-19: Elevated C5a-C5AR1 signaling correlates with severe lung inflammation; recombinant proteins aid in studying alveolar injury mechanisms .
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Cardiac Regeneration: C5AR1 inhibition attenuates cardiomyocyte proliferation post-injury in zebrafish, axolotl, and neonatal mouse models .
Therapeutic Development
Recombinant Gorilla C5AR1 is used to screen inhibitors like:
| Drug | Phase | Target Disease |
|---|---|---|
| Avacopan | Approved | ANCA-associated vasculitis |
| PMX-53 | Phase 2 | Atopic dermatitis |
| PMX205 | Preclinical | Neurodegenerative disorders |
Challenges and Future Directions
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Immunogenicity: Non-human primate-derived proteins may trigger immune responses in humanized models .
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Functional variability: Post-translational modifications differ across expression systems, affecting ligand affinity .
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Therapeutic potential: Ongoing trials explore C5AR1 antagonists for cancer immunotherapy and COVID-19-related acute lung injury .
Product Specs
Note: We will prioritize shipping the format currently in stock. However, if you have specific format requirements, please indicate them in your order. We will fulfill your request if possible.
Note: All of our proteins are shipped with standard blue ice packs. If dry ice shipping is required, please inform us in advance. Additional fees may apply.
Generally, the shelf life of the liquid form is 6 months at -20°C/-80°C. The shelf life of the lyophilized form is 12 months at -20°C/-80°C.
Target Background
KEGG: ggo:101126529
STRING: 9593.ENSGGOP00000008426
