Recombinant Gorilla gorilla gorilla Securin (PTTG1)
Shipped with Ice Packs 
In Stock 
Product Specs
Form
Lyophilized powder. We will ship the available format, but you can request a specific format when ordering.
Lead Time
Delivery times vary by purchase method and location. Consult local distributors for specifics. Proteins are shipped with blue ice packs by default; request dry ice in advance (extra fees apply).
Notes
Avoid repeated freeze-thaw cycles. Working aliquots are stable at 4°C for up to one week.
Reconstitution
Briefly centrifuge the vial before opening. Reconstitute in sterile deionized water to 0.1-1.0 mg/mL. Add 5-50% glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final glycerol concentration is 50%.
Shelf Life
Shelf life depends on storage conditions, buffer, temperature, and protein stability. Liquid form: 6 months at -20°C/-80°C. Lyophilized form: 12 months at -20°C/-80°C.
Storage Condition
Store at -20°C/-80°C upon receipt. Aliquot for multiple uses. Avoid repeated freeze-thaw cycles.
Tag Info
Tag type is determined during manufacturing. Specify your desired tag type, and we will prioritize its development.
Synonyms
PTTG1; Securin; Pituitary tumor-transforming gene 1 protein
Buffer Before Lyophilization
Tris/PBS-based buffer, 6%
Trehalose.
Datasheet
Please contact us to get it.
Expression Region
2-202
Protein Length
Full Length of Mature Protein
Purity
>85% (SDS-PAGE)
Species
Gorilla gorilla gorilla (Western lowland gorilla)
Target Names
Target Protein Sequence
ATLIYVDKE NGEPGTRVAA KDGLKLGSAP SIKALDGRSQ VSTPRFGKTF DAPPALPKAT
RKALGTVNRA TEKSVKTKGP LKQKQPSFSA KKMTEKTVKA KSSVPASDDA YPEIEKFFPF
NPLDFESFDL PEEHQIAHLP LSGVPLMILD EERELEKLFQ LGPPSPVRMP SPPWESNLLQ
SPSSILSTLD VELPPVCCDI DI
Uniprot No.
Target Background
Function
Securin is a regulatory protein crucial for chromosome stability, the p53 pathway, and DNA repair. It likely functions by blocking key proteins. During mitosis, it inhibits Separase, preventing cohesin cleavage and chromosome segregation. In anaphase, Securin is ubiquitinated and degraded, releasing Separase. It's not just an inhibitor; it's also needed to activate Separase. Securin negatively regulates p53 activity and its related apoptosis. This may explain its transforming potential when overexpressed. It may also contribute to DNA repair via interaction with Ku, potentially linking DNA damage responses to sister chromatid separation.
Database Links
STRING: 9593.ENSGGOP00000016528
Protein Families
Securin family
Subcellular Location
Cytoplasm. Nucleus.
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