Recombinant Human Catechol O-methyltransferase domain-containing protein 1 (COMTD1)
Description
Introduction to Recombinant Human Catechol O-methyltransferase Domain-Containing Protein 1 (COMTD1)
Recombinant Human Catechol O-methyltransferase domain-containing protein 1 (COMTD1) is a protein produced through recombinant DNA technology, typically in an in vitro E. coli expression system . This protein is encoded by the COMTD1 gene, which is identified by the Gene ID 118881 in the human genome . Despite its classification as a catechol O-methyltransferase domain-containing protein, the biological function of COMTD1 remains poorly understood, although recent studies have begun to shed light on its potential roles.
Biological Function and Localization
Recent research has shown that COMTD1 is localized to mitochondria in pigment cells . A study involving a frame-shift mutation in the COMTD1 gene demonstrated that this mutation is associated with impaired production of pheomelanin, a type of melanin. The study suggests that COMTD1 may protect pigment cells from oxidative stress, which is crucial for the synthesis of pheomelanin . This protective role could potentially extend to other cell types as well.
Research Findings and Clinical Implications
COMTD1 has been identified as one of the genes involved in DNA methylation analyses, alongside other genes like HTR1E, which are functionally related to serotonin receptors . Additionally, COMTD1 has been implicated in cancer research, particularly in breast cancer (BC), where it is part of a prognostic model that predicts patient outcomes . The model incorporates COMTD1 along with other mitochondrial-related genes to stratify BC patients into high-risk and low-risk groups based on their expression levels.
Recombinant Production and Applications
Recombinant Human COMTD1 is produced in an E. coli expression system, which allows for controlled and efficient production of the protein for research purposes . This recombinant protein can be used in various biochemical assays to study its enzymatic activity, interactions, and potential therapeutic applications.
Table 1: Information on Recombinant Human COMTD1
| Parameter | Description |
|---|---|
| Gene ID | 118881 |
| Source | E. coli expression system |
| Function | O-methyltransferase domain-containing protein |
| Localization | Mitochondria in pigment cells |
Table 2: Research Implications
Product Specs
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Target Background
Putative O-methyltransferase.
