Recombinant Human Interleukin-17A protein (IL17A)
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Description
Biological Functions and Mechanisms
IL-17A is secreted by Th17 cells, γδ T cells, neutrophils, and Paneth cells . Its roles include:
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Proinflammatory Effects:
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Immune Regulation:
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Dual Roles in Disease:
Inflammatory and Autoimmune Disease Models
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Rheumatoid Arthritis: IL-17A synergizes with TNF-α to activate synovial fibroblasts, driving joint destruction .
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Psoriasis: Overexpression in keratinocytes amplifies epidermal hyperplasia and neutrophil infiltration .
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Inflammatory Bowel Disease (IBD): Paradoxically, IL-17A deficiency exacerbates colitis in murine models, highlighting its tissue-protective role .
Cancer Immunology
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Pro-Tumor Effects: Promotes angiogenesis and suppresses antitumor immunity in certain cancers .
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Anti-Tumor Effects: Enhances neutrophil-mediated cytotoxicity in esophageal squamous cell carcinoma .
Metabolic Regulation
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IL-17A induces CPT1A in fibroblasts, facilitating glucose uptake for cell survival during inflammation .
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Itaconate, a metabolite, inhibits IL-17A-driven IκBζ activation, suggesting therapeutic potential .
Therapeutic Implications
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Targeted Therapies: Anti-IL-17A biologics (e.g., secukinumab) are FDA-approved for psoriasis and ankylosing spondylitis .
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Risks: IL-17A blockade may worsen Crohn’s disease due to impaired epithelial repair .
Key Research Advances
Challenges and Future Directions
Product Specs
Buffer
0.2 µm filtered PBS, pH 7.4, lyophilized
Form
Liquid or lyophilized powder
Lead Time
5-10 business days
Shelf Life
Shelf life depends on several factors: storage conditions, buffer composition, temperature, and protein stability. Generally, liquid formulations have a 6-month shelf life at -20°C/-80°C, while lyophilized formulations have a 12-month shelf life at -20°C/-80°C.
Storage Condition
Upon receipt, store at -20°C/-80°C. Aliquot for multiple uses. Avoid repeated freeze-thaw cycles.
Tag Info
Tag-free
Synonyms
CTLA 8; CTLA-8; CTLA8; cytotoxic T lymphocyte associated antigen 8; Cytotoxic T lymphocyte associated protein 8; Cytotoxic T lymphocyte associated serine esterase 8; Cytotoxic T-lymphocyte-associated antigen 8; IL 17; IL 17A; IL-17; IL-17A; IL17; IL17_HUMAN; Il17a; Interleukin 17 (cytotoxic T lymphocyte associated serine esterase 8); interleukin 17A; Interleukin-17A; interleukin17; Interleukin17A; OTTHUMP00000016597; OTTMUSP00000046003
Datasheet & Coa
Please contact us to get it.
Expression Region
24-155aa
Mol. Weight
15.1 kDa/30.2kDa
Protein Length
Full Length of Mature Protein
Purity
>95% as determined by SDS-PAGE.
Research Area
Immunology
Source
E.Coli
Species
Homo sapiens (Human)
Target Names
Uniprot No.
Target Background
Function
Interleukin-17A (IL-17A) is an effector cytokine crucial to both innate and adaptive immune responses. It plays a vital role in antimicrobial defense and tissue homeostasis. IL-17A signals through the IL17RA-IL17RC heterodimeric receptor complex, triggering interactions between IL17RA and IL17RC chains with the TRAF3IP2 adapter. This leads to TRAF6-mediated activation of NF-κB and MAP kinase pathways, resulting in the transcriptional activation of cytokines, chemokines, antimicrobial peptides, and matrix metalloproteinases, potentially causing significant immune inflammation. IL-17A bridges adaptive T cell-mediated immunity and acute inflammatory responses to eliminate extracellular bacteria and fungi. As a key effector cytokine of T helper 17 (Th17) cells, it primarily activates and recruits neutrophils to infection and inflammation sites. In airway epithelium, it mediates neutrophil chemotaxis by inducing CXCL1 and CXCL5 chemokines. In secondary lymphoid organs, it promotes germinal center formation by regulating B cell chemotaxis toward CXCL12 and CXCL13, enhancing B cell retention within germinal centers, somatic hypermutation rates, and selection toward plasma cells. IL-17A also functions as an effector cytokine in a subset of γδ T cells, contributing to an inflammatory circuit downstream of IL-1β, TLR2, and IL23A-IL12B to promote neutrophil recruitment and efficient bacterial clearance. It is also an effector cytokine of innate immune cells, including invariant natural killer T (iNKT) cells and group 3 innate lymphoid cells, mediating initial neutrophilic inflammation. IL-17A maintains epithelial barrier integrity during homeostasis and infection. Following acute injury, it directly contributes to epithelial barrier formation by regulating occludin localization and tight junction biogenesis. As part of the mucosal immune response to commensal bacteria, it enhances resistance to pathogenic bacterial and fungal infections by promoting neutrophil recruitment and antimicrobial peptide release. It also contributes to antiviral defense through multiple mechanisms, enhancing immunity against West Nile virus by promoting T cell cytotoxicity and potentially playing a beneficial role in influenza A virus (H5N1) infection by enhancing B cell recruitment and immune response in the lung and contributing to influenza A virus (H1N1) clearance by driving B-1a B cell differentiation, leading to the production of virus-specific IgM antibodies as a first line of defense.
Gene References Into Functions
A proliferation potential-related protein promotes esophageal cancer cell proliferation and migration, and suppresses apoptosis by mediating the expression of p53 and IL-17., 30223275, https://www.ncbi.nlm.nih.gov/pubmed/30223275, .
The pooled estimate revealed an association between IL-17A rs2275913 polymorphism and the risk of gastric cancer (GC) under all genetic models., 29860554, https://www.ncbi.nlm.nih.gov/pubmed/29860554, .
Over-expression of IL-17 and IL-27 is involved in the pathogenesis of liver damage in children with human cytomegalovirus infection., 30022757, https://www.ncbi.nlm.nih.gov/pubmed/30022757, .
IL-23 and IL-17 have roles in the pathogenesis of Tunisian pemphigus foliaceus., 30116153, https://www.ncbi.nlm.nih.gov/pubmed/30116153, .
Findings support the association between IL-17 SNPs and the risk of asthma in the Chinese Han population from central China. The GA genotype of rs3748067 and the C allele carriers (CT+CC) of rs763780 were associated with a higher risk of asthma., 30036556, https://www.ncbi.nlm.nih.gov/pubmed/30036556, .
IL-17A and HPSE may promote tumor angiogenesis and cell proliferation and invasion in cervical cancer, possibly via the NF-κB signaling pathway., 30066843, https://www.ncbi.nlm.nih.gov/pubmed/30066843, .
The results suggest that IL17A (rs2275913) polymorphism is associated with the development of rheumatic heart disease in the South Indian population., 29985710, https://www.ncbi.nlm.nih.gov/pubmed/29985710, .
This study demonstrated the alteration of IL-17 levels in aseptic non-vasculitic cerebral sinovenous thrombosis., 30246697, https://www.ncbi.nlm.nih.gov/pubmed/30246697, .
In a Brazilian population, TNF and IL17 gene polymorphisms associated with the expression of important inflammatory cytokines were associated with overall spondyloarthritis, and specifically with ankylosing spondylitis and psoriatic arthritis, regardless of gender and HLA-B27., 29849482, https://www.ncbi.nlm.nih.gov/pubmed/29849482, .
The single nucleotide polymorphism rs2275913 in the IL-17A gene is associated with susceptibility to viral myocarditis., 29530464, https://www.ncbi.nlm.nih.gov/pubmed/29530464, .
IL-17A197AA polymorphism is associated with the risk of colorectal cancer., 29970680, https://www.ncbi.nlm.nih.gov/pubmed/29970680, .
Findings demonstrate that the AA genotype from the IL-17A rs2275913 SNP is positively associated with protection against active tuberculosis but related to higher disease severity in the Argentinean population., 28098168, https://www.ncbi.nlm.nih.gov/pubmed/28098168, .
Results suggest that the effects of IL-17 mediate activation of STAT3 signaling in breast cancer cells. Targeting IL-17/STAT3 signaling may be a promising strategy for breast cancer treatment., 29655056, https://www.ncbi.nlm.nih.gov/pubmed/29655056, .
This study concludes that the presence of IL-17 polymorphism rs2275913 is related to a more severe form of the disease and a higher number of disease-modifying antirheumatic drugs required to control it, and may confer a risk of developing rheumatoid arthritis in Mexican carriers., 28379210, https://www.ncbi.nlm.nih.gov/pubmed/28379210, .
Polymorphisms of IL-17 are associated with host susceptibility to some bacterial pathogens., 29345518, https://www.ncbi.nlm.nih.gov/pubmed/29345518, .
Secreted IL-17A is not responsible for the second hit in acute pancreatitis., 29422392, https://www.ncbi.nlm.nih.gov/pubmed/29422392, .
Increased IL-17 and IFN-γ levels were observed following stimulation with *S. aureus* strains., 29311230, https://www.ncbi.nlm.nih.gov/pubmed/29311230, .
IL17A G197A is associated with higher susceptibility to oral lichen planus (OLP), and these patients exhibit significantly increased serum IL17A levels., 28741807, https://www.ncbi.nlm.nih.gov/pubmed/28741807, .
Findings highlight a regulatory pathway of Tiam1/Rac1 in Th17 cells and suggest it may be a therapeutic target in multiple sclerosis., 27725632, https://www.ncbi.nlm.nih.gov/pubmed/27725632, .
Interleukin 17A (IL-17[G197G]) was associated with preterm birth (PTB), and the PTB group had lower IL-17A expression compared to the full-term group., 29431293, https://www.ncbi.nlm.nih.gov/pubmed/29431293, .
In mouse and human pancreatic tumors and precursors, immune cell-derived IL-17 regulated development of tuft cells and stem cell features of pancreatic cancer cells via increased expression of DCLK1, POU2F3, ALDH1A1, and IL17RC., 29604293, https://www.ncbi.nlm.nih.gov/pubmed/29604293, .
Expression of miR-135a in cancer cells isolated from nasopharyngeal tumors was significantly lower than that in NP69 cells, and suppression of IL-17 by miR-135a mimic resulted in significant inhibition of nasopharyngeal carcinoma (NPC) cell proliferation., 29734196, https://www.ncbi.nlm.nih.gov/pubmed/29734196, .
IL-17 and IL-12 expression levels are reported in patients with lupus miliaris disseminatus faciei and healthy controls., 27515793, https://www.ncbi.nlm.nih.gov/pubmed/27515793, .
The variants +2199 A/C IL-23R and -197 G/A IL-17A could contribute to rheumatoid arthritis development., 28547498, https://www.ncbi.nlm.nih.gov/pubmed/28547498, .
IL-17A rs2275913 polymorphism did not influence RA susceptibility in the Tunisian population., 29584788, https://www.ncbi.nlm.nih.gov/pubmed/29584788, .
Results suggest that IL17A stimulated keratinocytes activated PI3K/AKT/mTOR signaling and inhibited autophagy by inhibiting autophagosome formation and enhancing autophagic flux., 29432814, https://www.ncbi.nlm.nih.gov/pubmed/29432814, .
This review discusses the cellular sources, modes of action, and regulation of IL-17 and IL-33 in hypersensitive diseases., 29153708, https://www.ncbi.nlm.nih.gov/pubmed/29153708, .
Interleukin-17A is a potential mediator of neuroanatomical remodeling of gut innervation during inflammatory bowel diseases., 28560787, https://www.ncbi.nlm.nih.gov/pubmed/28560787, .
This review discusses IL-17A's potential role in chronic obstructive pulmonary disease (COPD) pathogenesis. Targeting IL-17 signaling may mitigate inflammatory processes and prevent COPD progression., 28438639, https://www.ncbi.nlm.nih.gov/pubmed/28438639, .
The rs2275913 gene polymorphism is associated with a risk of Bacillus Calmette-Guérin (BCG) osteitis after vaccination., 28731539, https://www.ncbi.nlm.nih.gov/pubmed/28731539, .
Higher baseline Interleukin 17 levels are associated with greater symptomatic reduction in depressed patients treated with a bupropion-SSRI combination., 28698115, https://www.ncbi.nlm.nih.gov/pubmed/28698115, .
The IL-23/IL-17 axis and biochemical markers in the pathogenesis of type 2 diabetes are discussed., 28757426, https://www.ncbi.nlm.nih.gov/pubmed/28757426, .
Higher TGF-β mRNA levels were observed in biopsies from healthy controls, and IL-23 mRNA levels were significantly increased in the peri-implantitis group. No differences in IL-17 mRNA levels were observed between the two groups., 27062688, https://www.ncbi.nlm.nih.gov/pubmed/27062688, .
Interleukin-17 (IL-17) expression levels in blood and skin of atopic dermatitis (AD) patients and controls were studied., 28279075, https://www.ncbi.nlm.nih.gov/pubmed/28279075, .
Semen IL-17 and IL-18 levels in diabetic males were significantly higher than in normal males and were positively correlated with blood glucose level and sperm DNA fragmentation index., 28858634, https://www.ncbi.nlm.nih.gov/pubmed/28858634, .
The clinical significance of IL-17 and IL-23 in the pathogenesis of different types of gastric neoplasms is reported., 27869179, https://www.ncbi.nlm.nih.gov/pubmed/27869179, .
The IL-17A (-832A/G) polymorphism was not associated with accelerated silicosis., 28481151, https://www.ncbi.nlm.nih.gov/pubmed/28481151, .
IL-17A was significantly upregulated in patients with uncontrolled and refractory asthma. Its high level, in combination with upregulated Th2 and other cytokines, may indicate a refractory endotype of asthma., 28840844, https://www.ncbi.nlm.nih.gov/pubmed/28840844, .
IL17A participates in the human immune response against *M. tuberculosis* through autophagy activation, correlating with disease severity., 28581888, https://www.ncbi.nlm.nih.gov/pubmed/28581888, .
Serum from psoriasis patients had higher and a broader range of concentrations of IL-17 proteins compared to healthy volunteers., 28534291, https://www.ncbi.nlm.nih.gov/pubmed/28534291, .
SNPs of rs3819024 in IL-17A and rs763780 in IL-17F were weakly related to tuberculosis prognosis., 27339100, https://www.ncbi.nlm.nih.gov/pubmed/27339100, .
Aberrant NKG2D expression with IL-17 production of CD4+ T subsets was observed in patients with type 2 diabetes., 27168217, https://www.ncbi.nlm.nih.gov/pubmed/27168217, .
Luciferase assays revealed transcriptional regulation of IL-17F. Smad1/5/8 inhibitor pretreatment decreased IL-17F expression., 28812969, https://www.ncbi.nlm.nih.gov/pubmed/28812969, .
Increased IL-17A expression in early tendinopathy suggests its role as an inflammatory regulator in tendon remodeling., 27263531, https://www.ncbi.nlm.nih.gov/pubmed/27263531, .
IL-17A is a pro-inflammatory player in atherosclerosis; its expression is associated with increased inflammation and plaque vulnerability., 28034277, https://www.ncbi.nlm.nih.gov/pubmed/28034277, .
Asymmetric cell divisions in psoriasis are IL-17A-dependent., 28600817, https://www.ncbi.nlm.nih.gov/pubmed/28600817, .
Serum IL-23 and IL-17 levels were elevated in patients with aneurysmal subarachnoid hemorrhage (aSAH), showing upregulation of the IL-23/IL-17 inflammatory axis after aSAH., 28609751, https://www.ncbi.nlm.nih.gov/pubmed/28609751, .
IL-17-mediated immunity plays a dual role in chronic cystic fibrosis airways infection by *P. aeruginosa*: contributing to pathogen control and exacerbating pulmonary neutrophilia and tissue remodeling., 27189736, https://www.ncbi.nlm.nih.gov/pubmed/27189736, .
γδ T cells, not Th17 cells, are the principal IL-17 producers in acute gouty arthritis during acute flares., 29476737, https://www.ncbi.nlm.nih.gov/pubmed/29476737, .
High expression of IL-17A and IL-32 enhances T cell responses in breast tumors., 28470472, https://www.ncbi.nlm.nih.gov/pubmed/28470472, .
The pooled estimate revealed an association between IL-17A rs2275913 polymorphism and the risk of gastric cancer (GC) under all genetic models., 29860554, https://www.ncbi.nlm.nih.gov/pubmed/29860554, .
Over-expression of IL-17 and IL-27 is involved in the pathogenesis of liver damage in children with human cytomegalovirus infection., 30022757, https://www.ncbi.nlm.nih.gov/pubmed/30022757, .
IL-23 and IL-17 have roles in the pathogenesis of Tunisian pemphigus foliaceus., 30116153, https://www.ncbi.nlm.nih.gov/pubmed/30116153, .
Findings support the association between IL-17 SNPs and the risk of asthma in the Chinese Han population from central China. The GA genotype of rs3748067 and the C allele carriers (CT+CC) of rs763780 were associated with a higher risk of asthma., 30036556, https://www.ncbi.nlm.nih.gov/pubmed/30036556, .
IL-17A and HPSE may promote tumor angiogenesis and cell proliferation and invasion in cervical cancer, possibly via the NF-κB signaling pathway., 30066843, https://www.ncbi.nlm.nih.gov/pubmed/30066843, .
The results suggest that IL17A (rs2275913) polymorphism is associated with the development of rheumatic heart disease in the South Indian population., 29985710, https://www.ncbi.nlm.nih.gov/pubmed/29985710, .
This study demonstrated the alteration of IL-17 levels in aseptic non-vasculitic cerebral sinovenous thrombosis., 30246697, https://www.ncbi.nlm.nih.gov/pubmed/30246697, .
In a Brazilian population, TNF and IL17 gene polymorphisms associated with the expression of important inflammatory cytokines were associated with overall spondyloarthritis, and specifically with ankylosing spondylitis and psoriatic arthritis, regardless of gender and HLA-B27., 29849482, https://www.ncbi.nlm.nih.gov/pubmed/29849482, .
The single nucleotide polymorphism rs2275913 in the IL-17A gene is associated with susceptibility to viral myocarditis., 29530464, https://www.ncbi.nlm.nih.gov/pubmed/29530464, .
IL-17A197AA polymorphism is associated with the risk of colorectal cancer., 29970680, https://www.ncbi.nlm.nih.gov/pubmed/29970680, .
Findings demonstrate that the AA genotype from the IL-17A rs2275913 SNP is positively associated with protection against active tuberculosis but related to higher disease severity in the Argentinean population., 28098168, https://www.ncbi.nlm.nih.gov/pubmed/28098168, .
Results suggest that the effects of IL-17 mediate activation of STAT3 signaling in breast cancer cells. Targeting IL-17/STAT3 signaling may be a promising strategy for breast cancer treatment., 29655056, https://www.ncbi.nlm.nih.gov/pubmed/29655056, .
This study concludes that the presence of IL-17 polymorphism rs2275913 is related to a more severe form of the disease and a higher number of disease-modifying antirheumatic drugs required to control it, and may confer a risk of developing rheumatoid arthritis in Mexican carriers., 28379210, https://www.ncbi.nlm.nih.gov/pubmed/28379210, .
Polymorphisms of IL-17 are associated with host susceptibility to some bacterial pathogens., 29345518, https://www.ncbi.nlm.nih.gov/pubmed/29345518, .
Secreted IL-17A is not responsible for the second hit in acute pancreatitis., 29422392, https://www.ncbi.nlm.nih.gov/pubmed/29422392, .
Increased IL-17 and IFN-γ levels were observed following stimulation with *S. aureus* strains., 29311230, https://www.ncbi.nlm.nih.gov/pubmed/29311230, .
IL17A G197A is associated with higher susceptibility to oral lichen planus (OLP), and these patients exhibit significantly increased serum IL17A levels., 28741807, https://www.ncbi.nlm.nih.gov/pubmed/28741807, .
Findings highlight a regulatory pathway of Tiam1/Rac1 in Th17 cells and suggest it may be a therapeutic target in multiple sclerosis., 27725632, https://www.ncbi.nlm.nih.gov/pubmed/27725632, .
Interleukin 17A (IL-17[G197G]) was associated with preterm birth (PTB), and the PTB group had lower IL-17A expression compared to the full-term group., 29431293, https://www.ncbi.nlm.nih.gov/pubmed/29431293, .
In mouse and human pancreatic tumors and precursors, immune cell-derived IL-17 regulated development of tuft cells and stem cell features of pancreatic cancer cells via increased expression of DCLK1, POU2F3, ALDH1A1, and IL17RC., 29604293, https://www.ncbi.nlm.nih.gov/pubmed/29604293, .
Expression of miR-135a in cancer cells isolated from nasopharyngeal tumors was significantly lower than that in NP69 cells, and suppression of IL-17 by miR-135a mimic resulted in significant inhibition of nasopharyngeal carcinoma (NPC) cell proliferation., 29734196, https://www.ncbi.nlm.nih.gov/pubmed/29734196, .
IL-17 and IL-12 expression levels are reported in patients with lupus miliaris disseminatus faciei and healthy controls., 27515793, https://www.ncbi.nlm.nih.gov/pubmed/27515793, .
The variants +2199 A/C IL-23R and -197 G/A IL-17A could contribute to rheumatoid arthritis development., 28547498, https://www.ncbi.nlm.nih.gov/pubmed/28547498, .
IL-17A rs2275913 polymorphism did not influence RA susceptibility in the Tunisian population., 29584788, https://www.ncbi.nlm.nih.gov/pubmed/29584788, .
Results suggest that IL17A stimulated keratinocytes activated PI3K/AKT/mTOR signaling and inhibited autophagy by inhibiting autophagosome formation and enhancing autophagic flux., 29432814, https://www.ncbi.nlm.nih.gov/pubmed/29432814, .
This review discusses the cellular sources, modes of action, and regulation of IL-17 and IL-33 in hypersensitive diseases., 29153708, https://www.ncbi.nlm.nih.gov/pubmed/29153708, .
Interleukin-17A is a potential mediator of neuroanatomical remodeling of gut innervation during inflammatory bowel diseases., 28560787, https://www.ncbi.nlm.nih.gov/pubmed/28560787, .
This review discusses IL-17A's potential role in chronic obstructive pulmonary disease (COPD) pathogenesis. Targeting IL-17 signaling may mitigate inflammatory processes and prevent COPD progression., 28438639, https://www.ncbi.nlm.nih.gov/pubmed/28438639, .
The rs2275913 gene polymorphism is associated with a risk of Bacillus Calmette-Guérin (BCG) osteitis after vaccination., 28731539, https://www.ncbi.nlm.nih.gov/pubmed/28731539, .
Higher baseline Interleukin 17 levels are associated with greater symptomatic reduction in depressed patients treated with a bupropion-SSRI combination., 28698115, https://www.ncbi.nlm.nih.gov/pubmed/28698115, .
The IL-23/IL-17 axis and biochemical markers in the pathogenesis of type 2 diabetes are discussed., 28757426, https://www.ncbi.nlm.nih.gov/pubmed/28757426, .
Higher TGF-β mRNA levels were observed in biopsies from healthy controls, and IL-23 mRNA levels were significantly increased in the peri-implantitis group. No differences in IL-17 mRNA levels were observed between the two groups., 27062688, https://www.ncbi.nlm.nih.gov/pubmed/27062688, .
Interleukin-17 (IL-17) expression levels in blood and skin of atopic dermatitis (AD) patients and controls were studied., 28279075, https://www.ncbi.nlm.nih.gov/pubmed/28279075, .
Semen IL-17 and IL-18 levels in diabetic males were significantly higher than in normal males and were positively correlated with blood glucose level and sperm DNA fragmentation index., 28858634, https://www.ncbi.nlm.nih.gov/pubmed/28858634, .
The clinical significance of IL-17 and IL-23 in the pathogenesis of different types of gastric neoplasms is reported., 27869179, https://www.ncbi.nlm.nih.gov/pubmed/27869179, .
The IL-17A (-832A/G) polymorphism was not associated with accelerated silicosis., 28481151, https://www.ncbi.nlm.nih.gov/pubmed/28481151, .
IL-17A was significantly upregulated in patients with uncontrolled and refractory asthma. Its high level, in combination with upregulated Th2 and other cytokines, may indicate a refractory endotype of asthma., 28840844, https://www.ncbi.nlm.nih.gov/pubmed/28840844, .
IL17A participates in the human immune response against *M. tuberculosis* through autophagy activation, correlating with disease severity., 28581888, https://www.ncbi.nlm.nih.gov/pubmed/28581888, .
Serum from psoriasis patients had higher and a broader range of concentrations of IL-17 proteins compared to healthy volunteers., 28534291, https://www.ncbi.nlm.nih.gov/pubmed/28534291, .
SNPs of rs3819024 in IL-17A and rs763780 in IL-17F were weakly related to tuberculosis prognosis., 27339100, https://www.ncbi.nlm.nih.gov/pubmed/27339100, .
Aberrant NKG2D expression with IL-17 production of CD4+ T subsets was observed in patients with type 2 diabetes., 27168217, https://www.ncbi.nlm.nih.gov/pubmed/27168217, .
Luciferase assays revealed transcriptional regulation of IL-17F. Smad1/5/8 inhibitor pretreatment decreased IL-17F expression., 28812969, https://www.ncbi.nlm.nih.gov/pubmed/28812969, .
Increased IL-17A expression in early tendinopathy suggests its role as an inflammatory regulator in tendon remodeling., 27263531, https://www.ncbi.nlm.nih.gov/pubmed/27263531, .
IL-17A is a pro-inflammatory player in atherosclerosis; its expression is associated with increased inflammation and plaque vulnerability., 28034277, https://www.ncbi.nlm.nih.gov/pubmed/28034277, .
Asymmetric cell divisions in psoriasis are IL-17A-dependent., 28600817, https://www.ncbi.nlm.nih.gov/pubmed/28600817, .
Serum IL-23 and IL-17 levels were elevated in patients with aneurysmal subarachnoid hemorrhage (aSAH), showing upregulation of the IL-23/IL-17 inflammatory axis after aSAH., 28609751, https://www.ncbi.nlm.nih.gov/pubmed/28609751, .
IL-17-mediated immunity plays a dual role in chronic cystic fibrosis airways infection by *P. aeruginosa*: contributing to pathogen control and exacerbating pulmonary neutrophilia and tissue remodeling., 27189736, https://www.ncbi.nlm.nih.gov/pubmed/27189736, .
γδ T cells, not Th17 cells, are the principal IL-17 producers in acute gouty arthritis during acute flares., 29476737, https://www.ncbi.nlm.nih.gov/pubmed/29476737, .
High expression of IL-17A and IL-32 enhances T cell responses in breast tumors., 28470472, https://www.ncbi.nlm.nih.gov/pubmed/28470472, .
Database Links
Protein Families
IL-17 family
Subcellular Location
Secreted.
Tissue Specificity
Expressed in memory Th17 cells (at protein level).
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