Recombinant Human Interleukin-17B protein (IL17B) (Active)

Shipped with Ice Packs
In Stock
Cat. No.
BT2018540
Synonyms
Cytokine like protein Zcyto7; Cytokine Zcyto7; IL 17B; IL 20 ; IL-17B; IL-20; IL17B; IL17B_HUMAN; IL20 ; Interleukin 17 beta; Interleukin 17B; Interleukin 20; Interleukin-17B; Interleukin-20; MGC138900; MGC138901; Neuronal interleukin 17 related factor ; Neuronal interleukin-17-related factor; NIRF ; ZCYTO7
Purity
>95% as determined by SDS-PAGE.
Quick Inquiry

Description

Receptor Binding

IL-17B binds specifically to IL-17RB but not IL-17R . It shares 88% sequence identity between humans and mice , enabling cross-species functional studies.

Biological Roles

  • Proinflammatory Effects: Stimulates TNF-α and IL-1β release in monocytes and IL-8 in hepatocytes .

  • Anti-inflammatory Modulation: Antagonizes IL-25-driven inflammation in colitis and asthma by suppressing IL-6 production in epithelial cells .

  • Tissue-Specific Expression: Highly expressed in the spinal cord, brain, and gastrointestinal tract .

Inflammatory Bowel Disease (IBD)

  • IL-17B deficiency exacerbates colitis in mice, increasing neutrophil infiltration and proinflammatory cytokines (e.g., S100A9) in macrophages .

  • Recombinant IL-17B administration reduces colitis severity by modulating myeloid cell responses .

Cancer and Bone Biology

  • Upregulated in aggressive breast cancer, promoting tumorigenicity via IL-17RB signaling .

  • Enhances vascular endothelial cell migration while inhibiting adhesion .

  • Expressed in bone collars and chondrocytes, influencing skeletal development and fracture repair .

Allergic Inflammation

  • Inhibits IL-25-mediated allergic asthma and parasitic defense pathways .

Therapeutic Potential

ConditionMechanismOutcome
ColitisSuppresses neutrophil infiltration and macrophage cytokines Reduced disease severity in murine models
Breast CancerEnhances IL-17RB signaling to promote tumor growth Potential oncotherapeutic target
ArthritisUpregulated in arthritic cartilage, exacerbating inflammation Contributes to joint destruction

Key Challenges and Future Directions

  • Dual Roles: IL-17B exhibits both pro- and anti-inflammatory effects depending on context .

  • Therapeutic Targeting: While promising in colitis, its role in cancer and arthritis requires careful modulation .

  • Mechanistic Gaps: The interplay between IL-17B and other IL-17 family members remains poorly understood .

Product Specs

Buffer
Lyophilized from a 0.2 µm filtered PBS, pH 7.4, containing 0.1% Tween-20 and 3% Trehalose.
Form
Lyophilized powder
Lead Time
5-10 business days
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Reconstitution
We recommend centrifuging this vial briefly prior to opening to ensure the contents settle to the bottom. Reconstitute the protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. We recommend adding 5-50% glycerol (final concentration) and aliquoting for long-term storage at -20°C/-80°C. Our default final glycerol concentration is 50%, which can be used as a reference.
Shelf Life
The shelf life depends on various factors including storage conditions, buffer ingredients, storage temperature, and the stability of the protein itself. Generally, the shelf life of the liquid form is 6 months at -20°C/-80°C, while the shelf life of the lyophilized form is 12 months at -20°C/-80°C.
Storage Condition
Store at -20°C/-80°C upon receipt. Aliquoting is necessary for multiple uses. Avoid repeated freeze-thaw cycles.
Tag Info
Tag-Free
Synonyms
Cytokine like protein Zcyto7; Cytokine Zcyto7; IL 17B; IL 20 ; IL-17B; IL-20; IL17B; IL17B_HUMAN; IL20 ; Interleukin 17 beta; Interleukin 17B; Interleukin 20; Interleukin-17B; Interleukin-20; MGC138900; MGC138901; Neuronal interleukin 17 related factor ; Neuronal interleukin-17-related factor; NIRF ; ZCYTO7
Datasheet & Coa
Please contact us to get it.
Expression Region
21-180aa
Mol. Weight
18.3 kDa
Protein Length
Full Length of Mature Protein
Purity
>95% as determined by SDS-PAGE.
Research Area
Immunology
Source
E.Coli
Species
Homo sapiens (Human)
Target Names
IL17B
Uniprot No.
Q9UHF5

Target Background

Function
Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1.
Gene References Into Functions
  1. Research indicates that IL-17B/IL-17RB signaling contributes to the growth and migration of tumor cells. PMID: 27146881
  2. Our findings suggest a novel mechanism whereby IL-17B enhances the progression of gastric cancer by activating mesenchymal stem cells. PMID: 28145881
  3. Segregation analysis revealed that variants c.475T>G in SKP1, c.671G>A in PROB1, and c.527G>A in IL17B within the 5q31.1-q35.3 linkage region, and c.850G>A in HKDC1 in the 10q22 locus, were completely linked to the phenotype in the studied Keratoconus family. PMID: 27703147
  4. This comprehensive review details the recognition of activity, signaling, and the roles of IL17B-IL17RB in breast cancer, leading to the identification of potential novel therapeutic mechanisms. PMID: 28160754
  5. Studies indicate that interleukin 17 (IL-17B)/interleukin 17 receptor B (IL-17RB) signaling plays a crucial role in pancreatic cancer malignancy. PMID: 26285835
  6. IL-17B-IL-17RB signaling promotes pancreatic cancer malignancy. PMID: 25732306
  7. Results demonstrate that amplified signaling of interleukin-17 receptor B (IL-17RB) and its ligand IL-17B promotes tumorigenicity in breast cancer cells and hinders acinus formation in immortalized normal mammary epithelial cells. PMID: 23851503
  8. IL-17B can enhance the effects of TNF-alpha on the production of cytokines and chemokines that regulate immune cell trafficking and neutrophil homeostasis in inflamed tissues. PMID: 24056520
  9. IL-17A, IL-17B, IL-17F and IL-23 in systemic lupus erythematosus patients were examined, and the correlation between levels of these cytokines and VEGF, PIGF, as well as the number of endothelial cells, was investigated. PMID: 23661335
  10. Expression and functional studies of IL-17B. PMID: 22394632
  11. IL-17 may play a significant role in the development of nasal polyps due to its overexpression. PMID: 16805377

Show More

Hide All

Database Links

HGNC: 5982

OMIM: 604627

KEGG: hsa:27190

STRING: 9606.ENSP00000261796

UniGene: Hs.156979

Protein Families
IL-17 family
Subcellular Location
Secreted.
Tissue Specificity
Expressed in adult pancreas, small intestine, stomach, spinal cord and testis. Less pronounced expression in prostate, colon mucosal lining, and ovary.

Quick Inquiry

Personal Email Detected
Please use an institutional or corporate email address for inquiries. Personal email accounts ( such as Gmail, Yahoo, and Outlook) are not accepted. *

Category

Service

THE BIOTEK
THE BioTek is a global biotech company offering highly purified proteins for research in cancer, apoptosis, development, endocrinology, immunology, neuroscience, proteases, and stem cells.
  • Contact
  • Address: 1925 E Maple Ave, El Segundo, CA 90245 United States
  • Phone : +1 201-285-7826
  • Email : info@thebiotek.com
  • Hours : Mon.-Fri. 9:00 AM - 5:00 PM
© Copyright 2024 Thebiotek. All Rights Reserved.