Recombinant Human Meiotic recombination protein REC114 (REC114)
Shipped with Ice Packs 
In Stock 
Product Specs
Form
Lyophilized powder
Note: While we prioritize shipping the format currently in stock, please specify your format preference in order notes for customized preparation.
Note: While we prioritize shipping the format currently in stock, please specify your format preference in order notes for customized preparation.
Lead Time
Delivery times vary depending on the purchasing method and location. Please consult your local distributor for precise delivery estimates.
Note: Standard shipping includes blue ice packs. Dry ice shipping requires advance notification and incurs additional charges.
Note: Standard shipping includes blue ice packs. Dry ice shipping requires advance notification and incurs additional charges.
Notes
Avoid repeated freeze-thaw cycles. Store working aliquots at 4°C for up to one week.
Reconstitution
Centrifuge the vial briefly before opening to collect the contents. Reconstitute the protein in sterile deionized water to a concentration of 0.1-1.0 mg/mL. For long-term storage, we recommend adding 5-50% glycerol (final concentration) and aliquoting at -20°C/-80°C. Our standard glycerol concentration is 50%, provided as a guideline.
Shelf Life
Shelf life depends on several factors including storage conditions, buffer composition, temperature, and protein stability. Generally, liquid formulations have a 6-month shelf life at -20°C/-80°C, while lyophilized forms have a 12-month shelf life at -20°C/-80°C.
Storage Condition
Upon receipt, store at -20°C/-80°C. Aliquoting is essential for multiple uses. Avoid repeated freeze-thaw cycles.
Tag Info
Tag type is determined during manufacturing.
The specific tag type is determined during production. If you require a specific tag, please inform us, and we will prioritize its development.
The specific tag type is determined during production. If you require a specific tag, please inform us, and we will prioritize its development.
Synonyms
REC114; C15orf60; Meiotic recombination protein REC114
Buffer Before Lyophilization
Tris/PBS-based buffer, 6%
Trehalose.
Datasheet
Please contact us to get it.
Expression Region
1-266
Protein Length
full length protein
Purity
>85% (SDS-PAGE)
Species
Homo sapiens (Human)
Target Names
REC114
Target Protein Sequence
MAEAGKVPLS LGLTGGEAAE WPLQRYARCI PSNTRDPPGP CLEAGTAPCP TWKVFDSNEE
SGYLVLTIVI SGHFFIFQGQ TLLEGFSLIG SKDWLKIVRR VDCLLFGTTI KDKSRLFRVQ
FSGESKEQAL EHCCSCVQKL AQYITVQVPD GNIQELQLIP GPPRATESQG KDSAKSVPRQ
PGSHQHSEQQ QVCVTAGTGA PDGRTSLTQL AQTLLASEEL PHVYEQSAWG AEELGPFLRL
CLMDQNFPAF VEEVEKELKK LAGLRN
Uniprot No.
Target Background
Function
REC114 is essential for DNA double-strand break (DSB) formation in unsynapsed regions during meiotic recombination. It likely functions by forming a complex with IHO1 and MEI4, activating DSB formation in these unsynapsed regions—a crucial step for complete synapsis.
Gene References Into Functions
- In Japanese individuals, combined genotyping for HLA-A*02:06, TLR3 rs3775296 T/T, and Rec114 rs16957893 CG variants may predict the risk of cold medicine-related Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) with severe ocular complications. [PMID: 28100913](https://www.ncbi.nlm.nih.gov/pubmed/28100913)
Database Links
Protein Families
REC114 family
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