Recombinant Human Mucin-21 (MUC21), partial
Description
Introduction to Recombinant Human Mucin-21 (MUC21), partial
Recombinant Human Mucin-21 (MUC21), partial, refers to a recombinantly produced fragment of the MUC21 protein. MUC21 is a transmembrane mucin that plays a crucial role in forming mucous barriers on epithelial cells, providing protection to the cell surface and contributing to immune evasion mechanisms in cancer cells . The recombinant form of MUC21 is typically produced in bacterial systems like E. coli and is used for research purposes, including studying its role in cancer immunotherapy and its potential as a therapeutic target .
Structure and Function of MUC21
MUC21 is part of the mucin family, which includes proteins rich in proline, threonine, and serine (PTS domains). These domains are heavily O-glycosylated, contributing to the mucin's protective and structural functions . The recombinant partial MUC21 is often expressed in specific regions of the protein, such as the extracellular domain, to study its interactions and biological effects.
| Feature | Description |
|---|---|
| Expression System | Typically produced in E. coli |
| Expression Region | Partial, often focusing on the extracellular domain |
| Function | Forms mucous barriers, involved in immune evasion |
Research Findings on MUC21
Recent studies have highlighted MUC21's role in cancer, particularly in lung cancer, where it is overexpressed and correlates with reduced immune cell infiltration and responsiveness to immunotherapies . MUC21 acts by creating steric hindrance that prevents immune cells from interacting with cancer cells, thus facilitating immune evasion . Additionally, MUC21 has been shown to promote the viability and migration of glioblastoma cells .
| Cancer Type | MUC21's Role |
|---|---|
| Lung Cancer | Overexpressed, reduces immune cell infiltration and responsiveness to immunotherapy |
| Glioblastoma | Promotes cell viability and migration |
Recombinant Production and Applications
The recombinant production of MUC21 fragments allows for detailed studies of its structure and function. This includes understanding its glycosylation patterns and developing monoclonal antibodies against specific glycoforms . Such research is crucial for developing targeted therapies against MUC21 in cancer treatment.
Product Specs
Note: While we prioritize shipping the format currently in stock, please specify your format preference in order remarks for customized preparation.
Note: All proteins are shipped with standard blue ice packs. Dry ice shipping requires prior arrangement and incurs additional charges.
The tag type is determined during production. If you require a specific tag, please inform us, and we will prioritize its development.
Target Background
- The CC genotype of rs886403 in MUC21 is associated with colorectal cancer recurrence. PMID: 27803053
- MUC21 is significantly upregulated in human masticatory mucosa during wound healing. PMID: 28005267
- Mucin 21/epiglycanin modulates cell adhesion. PMID: 20388707
- Identification and expression of human epiglycanin/MUC21: a novel transmembrane mucin. PMID: 17977904
- Observational study of gene-disease association. (HuGE Navigator) PMID: 19851445
