Recombinant Human Olfactory receptor 2A2 (OR2A2)
Description
Functional Role in Olfaction
As an odorant receptor, OR2A2 detects volatile chemical compounds, initiating signal transduction via Gₒₗf proteins. Activation triggers cAMP-mediated calcium influx, depolarizing olfactory neurons . While its specific ligands are unknown, OR2A2’s broad ligand selectivity aligns with combinatorial odor-coding principles observed in other ORs .
Research Applications
OR2A2 is commercially available in two recombinant forms:
Antibody tools for OR2A2 detection:
Expression and Localization
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Native tissue: Predominantly expressed in olfactory epithelium .
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Ectopic expression: Successfully produced in E. coli and wheat germ systems, though functional reconstitution in mammalian cells (e.g., Hana3A) remains unreported .
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Subcellular localization: Membrane-bound in heterologous systems, consistent with GPCR trafficking .
Research Challenges
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Deorphanization: No activating ligands identified to date, unlike related receptors (e.g., OR2W3 activated by nerol ).
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Structural data: No resolved crystal structures; homology models rely on bovine rhodopsin templates .
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Functional assays: Requires co-expression with chaperones (RTP1/2) for proper folding in heterologous systems .
Biological and Clinical Relevance
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Evolutionary conservation: Part of the primate-specific OR2A subfamily, pseudogenized in some lineages .
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Non-olfactory roles: While ORs like OR51E2 regulate sperm chemotaxis , OR2A2’s extra-nasal functions are unexplored.
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Disease associations: No direct links reported, though metalloprotein dysfunction in ORs may contribute to neurodegenerative disorders .
Future Directions
Product Specs
Note: While we prioritize shipping the format currently in stock, please specify your preferred format in order notes for customized preparation.
Note: All proteins are shipped with standard blue ice packs. Dry ice shipping requires prior arrangement and incurs additional charges.
The specific tag will be determined during production. If you require a particular tag, please specify it in your order; we will prioritize its development.
