Recombinant Human Protein NLRC3 (NLRC3), partial
Shipped with Ice Packs 
In Stock 
Product Specs
Form
Lyophilized powder
Note: While we prioritize shipping the format currently in stock, please specify your format preference in order notes for customized preparation.
Note: While we prioritize shipping the format currently in stock, please specify your format preference in order notes for customized preparation.
Lead Time
Delivery times vary depending on the purchasing method and location. Please consult your local distributor for precise delivery estimates.
Note: Our proteins are shipped with standard blue ice packs. Dry ice shipping requires prior arrangement and incurs additional charges.
Note: Our proteins are shipped with standard blue ice packs. Dry ice shipping requires prior arrangement and incurs additional charges.
Notes
Avoid repeated freeze-thaw cycles. Store working aliquots at 4°C for up to one week.
Reconstitution
Centrifuge the vial briefly before opening to collect the contents. Reconstitute the protein in sterile deionized water to a concentration of 0.1-1.0 mg/mL. For long-term storage, we recommend adding 5-50% glycerol (final concentration) and aliquoting at -20°C/-80°C. Our default glycerol concentration is 50% and can serve as a reference.
Shelf Life
Shelf life depends on various factors including storage conditions, buffer composition, temperature, and protein stability. Generally, liquid formulations have a 6-month shelf life at -20°C/-80°C, while lyophilized forms have a 12-month shelf life at -20°C/-80°C.
Storage Condition
Upon receipt, store at -20°C/-80°C. Aliquoting is essential for multiple uses. Avoid repeated freeze-thaw cycles.
Tag Info
Tag type is determined during the manufacturing process.
The tag type is determined during production. If you require a specific tag, please inform us, and we will prioritize its development.
The tag type is determined during production. If you require a specific tag, please inform us, and we will prioritize its development.
Synonyms
CARD15-like ; CARD15-like protein; Caterpiller 16.2; Caterpiller protein 16.2; CLR16.2; FLJ00348; NLR family CARD domain containing 3; Nlrc3; NLRC3_HUMAN; NOD-like receptor C3; NOD3; NOD3 protein; Nucleotide-binding oligomerization domain protein 3; Nucleotide-binding oligomerization domain protein 3 caterpiller 16.2; nucleotide-binding oligomerization domain; leucine rich repeat and CARD domain containing 3; Protein NLRC3
Buffer Before Lyophilization
Tris/PBS-based buffer, 6%
Trehalose.
Datasheet
Please contact us to get it.
Protein Length
Partial
Purity
>85% (SDS-PAGE)
Species
Homo sapiens (Human)
Target Names
NLRC3
Uniprot No.
Target Background
Function
NLRC3 is a negative regulator of the innate immune response. It attenuates signaling pathways activated by Toll-like receptors (TLRs) and the DNA sensor STING/TMEM173 in response to pathogen-associated molecular patterns (PAMPs), such as intracellular poly(dA:dT) (but not poly(I:C)), or DNA virus infection (e.g., Herpes simplex virus 1, HSV1). It may modulate TLR4 signaling by affecting TRAF6 ubiquitination, reducing activating Lys-63-linked ubiquitination while leaving degradative Lys-48-linked ubiquitination unaffected. NLRC3 inhibits the PI3K-AKT-mTOR pathway, potentially by directly interacting with the PI3K regulatory subunit p85 (PIK3R1/PIK3R2), disrupting its association with the catalytic subunit p110 (PIK3CA/PIK3CB/PIK3CD), and reducing p85 activation. Through its regulation of the PI3K-AKT-mTOR pathway, NLRC3 controls cell proliferation, predominantly in intestinal epithelial cells. It may also influence NOD1- or NOD2-mediated NF-κB activation and inflammatory responses by preventing NLRP3 inflammasome formation, CASP1 cleavage, and IL-1β maturation.
Gene References Into Functions
- NLRC3 promotes K48-linked polyubiquitination and degradation of IRAK1. PMID: 28731142
- NLRC3 interferes with NALP3 inflammasome assembly and activity by competing with ASC for pro-caspase-1 binding. PMID: 28584053
- NLRC3 and AIM2 gene reduction correlates with cancer progression. PMID: 26378020
- NLRC3 overexpression suppresses pro-caspase-1 cleavage and IL-1β processing in the context of NLRP3/cryopyrin inflammasome components. PMID: 25277106
- NLRC3 inhibits TLR-dependent NF-κB activation by interacting with TRAF6. PMID: 22863753
- This report describes the cloning and characterization of CLR16.2, a novel CATERPILLER gene on human chromosome 16, encoding a protein with a typical NBD-LRR configuration. PMID: 15705585
Database Links
Protein Families
NLRP family
Subcellular Location
Cytoplasm.
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