Recombinant Human Sialic acid-binding Ig-like lectin 5 (SIGLEC5)
Shipped with Ice Packs 
In Stock 
Product Specs
Form
Lyophilized powder
Note: We prioritize shipping the format currently in stock. However, if you have a specific format preference, please indicate it in your order notes. We will accommodate your request whenever possible.
Note: We prioritize shipping the format currently in stock. However, if you have a specific format preference, please indicate it in your order notes. We will accommodate your request whenever possible.
Lead Time
Delivery times may vary depending on your purchase method and location. Please consult your local distributors for specific delivery details.
Note: All proteins are shipped with standard blue ice packs. If you require dry ice shipping, please notify us in advance. Additional fees may apply.
Note: All proteins are shipped with standard blue ice packs. If you require dry ice shipping, please notify us in advance. Additional fees may apply.
Notes
Repeated freezing and thawing is discouraged. Store working aliquots at 4°C for up to one week.
Reconstitution
We recommend briefly centrifuging the vial before opening to ensure the contents settle at the bottom. Reconstitute the protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. We recommend adding 5-50% glycerol (final concentration) and aliquoting for long-term storage at -20°C/-80°C. Our default final glycerol concentration is 50%. This can serve as a reference for your own formulations.
Shelf Life
Shelf life is influenced by factors including storage conditions, buffer components, temperature, and the protein's inherent stability. Generally, liquid forms have a shelf life of 6 months at -20°C/-80°C, while lyophilized forms have a shelf life of 12 months at -20°C/-80°C.
Storage Condition
Upon receipt, store at -20°C/-80°C. Aliquoting is essential for multiple uses. Avoid repeated freeze-thaw cycles.
Tag Info
Tag type will be determined during the manufacturing process.
The specific tag type will be chosen during production. If you have a preference for a particular tag type, please inform us, and we will prioritize its implementation.
Synonyms
SIGLEC5; CD33L2; OBBP2; Sialic acid-binding Ig-like lectin 5; Siglec-5; CD33 antigen-like 2; Obesity-binding protein 2; OB-BP2; OB-binding protein 2; CD antigen CD170
Buffer Before Lyophilization
Tris/PBS-based buffer, 6%
Trehalose.
Datasheet
Please contact us to get it.
Expression Region
17-551
Protein Length
Full Length of Mature Protein
Species
Homo sapiens (Human)
Target Names
SIGLEC5
Target Protein Sequence
EKPVYELQVQKSVTVQEGLCVLVPCSFSYPWRSWYSSPPLYVYWFRDGEIPYYAEVVATNNPDRRVKPETQGRFRLLGDVQKKNCSLSIGDARMEDTGSYFFRVERGRDVKYSYQQNKLNLEVTALIEKPDIHFLEPLESGRPTRLSCSLPGSCEAGPPLTFSWTGNALSPLDPETTRSSELTLTPRPEDHGTNLTCQMKRQGAQVTTERTVQLNVSYAPQTITIFRNGIALEILQNTSYLPVLEGQALRLLCDAPSNPPAHLSWFQGSPALNATPISNTGILELRRVRSAEEGGFTCRAQHPLGFLQIFLNLSVYSLPQLLGPSCSWEAEGLHCRCSFRARPAPSLCWRLEEKPLEGNSSQGSFKVNSSSAGPWANSSLILHGGLSSDLKVSCKAWNIYGSQSGSVLLLQGRSNLGTGVVPAALGGAGVMALLCICLCLIFFLIVKARRKQAAGRPEKMDDEDPIMGTITSGSRKKPWPDSPGDQASPPGDAPPLEEQKELHYASLSFSEMKSREPKDQEAPSTTEYSEIKTSK
Uniprot No.
Target Background
Function
SIGLEC5, a putative adhesion molecule, facilitates sialic-acid dependent binding to cells. It binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface.
Gene References Into Functions
- PSGL1 and Siglec-5 are positioned in close proximity on the leukocyte surface. SPSGL1 acts as a ligand for Siglec-5 and interacts with its ectodomain. Siglec-5 plays a crucial role in PSGL1-mediated leukocyte rolling and the overall inflammatory response. PMID: 27892504
- An unbiased screen identified Hsp70 as a ligand for Siglec-5 and Siglec-14. Stimulation of Hsp70 through Siglec-5 triggers an anti-inflammatory signal, while stimulation through Siglec-14 elicits a pro-inflammatory response. PMID: 26459514
- Evidence suggests that the Siglec-5/14 genotype influences neutrophil responses to group B Streptococcus. PMID: 24799499
- Research indicates that secretory IgA is taken up by M cells via the Dectin-1 receptor, with Siglec-5 potentially acting as a co-receptor. PMID: 24068891
- These studies demonstrate that the Siglec5 carbohydrate recognition domain alone is sufficient for binding sialylated carbohydrates, providing a foundation for further exploration of its structure and function. PMID: 23321067
- Siglec-5 expression protects T cells from HIV-1 and apoptosis-induced cell death and contributes to the varying outcomes of HIV-1 infection in humans and chimpanzees. PMID: 22945238
- Human Siglec-5 inhibitory receptor and immunoglobulin A (IgA) have distinct binding sites within streptococcal beta protein. PMID: 21795693
- Siglec-5 expression correlates with a lack of proliferation in a specific subset of human cells and is upregulated by activation of chimpanzee but not human lymphocytes. PMID: 20231688
- The expression of Siglec-5 on cells of the myelomonocytic lineage and its expression modulation by inflammatory stimuli suggest a role for this protein in cell-cell interactions following microbial exposure. PMID: 12763136
- Siglec-5 can be classified as an inhibitory receptor with the potential to mediate SHP-1 and/or SHP-2-dependent signaling in the absence of tyrosine phosphorylation. PMID: 15769739
- Siglecs-5 did not exhibit interaction with sulfate derivatives of LacNAc or sulfated oligosaccharides containing sialic acid. PMID: 16732727
- Siglec-5 expression levels were high or detectable in bone marrow plasma from AML patients and serum from normal donors. PMID: 16828866
- Siglec-14 and Siglec-5 appear to be the first glycan binding paired receptors. The near-complete sequence identity of the amino-terminal part of human Siglec-14 and Siglec-5 suggests partial gene conversion between SIGLEC14 and SIGLEC5. PMID: 17012248
- Siglec-5 has been identified as a receptor for alpha-1-acid glycoprotein (AGP) 1 in human neutrophils. PMID: 17675532
- Structural implications of SIGLEC5-mediated sialoglycan recognition have been reported. PMID: 18022638
- Group B Streptococcus beta protein binding to Siglec-5 impairs leukocyte phagocytosis, oxidative burst, and extracellular trap production, promoting bacterial survival. PMID: 19596804
Database Links
Protein Families
Immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family
Subcellular Location
Membrane; Single-pass type I membrane protein.
Tissue Specificity
Expressed by monocytic/myeloid lineage cells. Found at high levels in peripheral blood leukocytes, spleen, bone marrow and at lower levels in lymph node, lung, appendix, placenta, pancreas and thymus. Expressed by monocytes and neutrophils but absent from
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