Recombinant Human Tectonin beta-propeller repeat-containing protein 1 (TECPR1), partial
Shipped with Ice Packs 
In Stock 
Product Specs
Form
Lyophilized powder
Note: We will prioritize shipping the format currently in stock. If you require a specific format, please specify this in your order notes. We will fulfill your request to the best of our ability.
Note: We will prioritize shipping the format currently in stock. If you require a specific format, please specify this in your order notes. We will fulfill your request to the best of our ability.
Lead Time
Delivery times vary depending on the purchasing method and location. Please contact your local distributor for precise delivery estimates.
Note: Our proteins are shipped with standard blue ice packs. Dry ice shipping is available upon request; please contact us in advance for pricing and arrangements.
Note: Our proteins are shipped with standard blue ice packs. Dry ice shipping is available upon request; please contact us in advance for pricing and arrangements.
Notes
Avoid repeated freeze-thaw cycles. Store working aliquots at 4°C for up to one week.
Reconstitution
Centrifuge the vial briefly before opening to collect the contents. Reconstitute the protein in sterile, deionized water to a concentration of 0.1-1.0 mg/mL. We recommend adding 5-50% glycerol (final concentration) and aliquoting for long-term storage at -20°C/-80°C. Our standard glycerol concentration is 50% and can serve as a guideline.
Shelf Life
Shelf life depends on various factors including storage conditions, buffer composition, temperature, and the protein's inherent stability. Generally, liquid formulations have a 6-month shelf life at -20°C/-80°C, while lyophilized forms have a 12-month shelf life at -20°C/-80°C.
Storage Condition
Store at -20°C/-80°C upon receipt. Aliquoting is recommended for multiple uses. Avoid repeated freeze-thaw cycles.
Tag Info
Tag type is determined during the manufacturing process.
The specific tag will be determined during production. If you require a particular tag type, please inform us, and we will prioritize its implementation.
The specific tag will be determined during production. If you require a particular tag type, please inform us, and we will prioritize its implementation.
Synonyms
2210010N04Rik; DKFZP434B0335; FLJ23419; FLJ90593; KIAA1358; MGC124730; mKIAA1358; RGD1306873; TCPR1_HUMAN; Tecpr1; tectonin beta propeller repeat containing 1; Tectonin beta-propeller repeat-containing protein 1
Buffer Before Lyophilization
Tris/PBS-based buffer, 6%
Trehalose.
Datasheet
Please contact us to get it.
Protein Length
Partial
Purity
>85% (SDS-PAGE)
Species
Homo sapiens (Human)
Target Names
TECPR1
Uniprot No.
Target Background
Function
Tectonin beta-propeller repeat-containing protein 1 (TECPR1) is a tethering factor involved in autophagy. It promotes autophagosome maturation by facilitating fusion between autophagosomes and lysosomes. This function is mediated through its interaction with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) found on autophagosome surfaces. TECPR1 also participates in selective autophagy targeting bacterial pathogens, being essential for phagophore/preautophagosomal structure biogenesis and maturation.
Gene References Into Functions
- The coordinated interactions between TECPR1, Atg12-Atg5, and PtdIns(3)P dictate the fusion specificity between autophagosomes and lysosomes. The formation of this complex initiates autophagosome maturation. PMID: 22342342
Database Links
Protein Families
TECPR1 family
Subcellular Location
Cytoplasmic vesicle, autophagosome membrane. Lysosome membrane. Note=Localizes to Lysosome membranes, and binds PtdIns(3)P at the surface of autophagosome. Localizes to autolysosomes, a vesicle formed by the fusion between autophagosomes and lysosomes.
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