Recombinant Human Transmembrane protein 244 (TMEM244)
Description
General Information
Recombinant Human Transmembrane protein 244 (TMEM244) is a protein-coding gene in humans .
Gene ID
The Gene ID for TMEM244 is 253582, updated on January 4, 2025 .
Function and Characteristics
TMEM244 is a transmembrane protein, but its exact function is not yet fully understood . Research indicates that TMEM244 is highly expressed in T-cell lymphoma (TCL) but not in T-cell acute lymphoblastic leukemia (T-ALL) .
Role in Diseases
Diseases associated with TMEM244 include Spermatogenic Failure 5, developmental and epileptic encephalopathy .
Diagnostic Accuracy
TMEM244 expression shows high accuracy in diagnosing TCL compared to T-ALL, with an area under the curve (AUC) of 99.4% (95% CI: 98.2-100%; P < 0.001) . A TMEM244 expression level greater than 1.5 indicates a sensitivity of 95.8% in diagnosing TCL .
TMEM214 and Apoptosis
It's important not to confuse TMEM244 with TMEM214. Transmembrane protein 214 (TMEM214) is a critical mediator of ER stress-induced apoptosis . TMEM214 is localized on the endoplasmic reticulum (ER) and is required for ER stress-induced caspase 4 activation and apoptosis .
TMEM214's Role
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Apoptosis Induction Overexpression of TMEM214 induces apoptosis .
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ER Stress Mediation Knockdown of TMEM214 inhibits ER stress-induced apoptosis but not apoptosis induced by TNFα, actinomycin D, or etoposide .
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Independence from CHOP and JNK TMEM214-mediated apoptosis is independent of CHOP induction or JNK phosphorylation .
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ER Localization TMEM214 is localized to the outer membrane of the ER .
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Procaspase 4 Interaction TMEM214 interacts with procaspase 4, which is essential for ER stress-induced apoptosis .
Product Specs
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