Recombinant Human Transmembrane protein 51 (TMEM51)
Description
Introduction to Recombinant Human Transmembrane Protein 51 (TMEM51)
Transmembrane protein 51 (TMEM51) is a protein-coding gene in humans . It is also known as C1orf72 and FLJ10199 . TMEM51 is located on chromosome 1 at position 1:15152532-15220478 (GRCh38) .
Gene ID and General Information
The gene ID for TMEM51 is 55092, and it was last updated on January 4, 2025 . Open Targets Genetics explores associations between traits, variants, and genes, including TMEM51, with a focus on multi-trait analysis and gene-to-variant scoring .
Role in Laryngeal Squamous Cell Carcinoma (LSCC)
Research indicates that TMEM51 plays a role in laryngeal squamous cell carcinoma (LSCC).
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lncRNA TMEM51-AS1: Long non-coding RNAs (lncRNAs) like TMEM51-AS1 can function as competing endogenous RNAs (ceRNAs) to interact with microRNAs (miRNAs) to regulate target genes, influencing cancer initiation and progression .
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CeRNA Network: TMEM51-AS1 functions as a ceRNA to regulate SNX21 (sorting nexin family member 21) and TRAPPC10 (trafficking protein particle complex 10) by sponging miR-106b .
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Methylation-mediated Upregulation: Methylation-mediated upregulation of lncRNA TMEM51-AS1 may function as a ceRNA for miR-106b to regulate SNX21 and TRAPPC10 .
TMEMs Role in Cell Proliferation, Migration, and EMT in Cancer
TMEMs play a role in cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) in cancer. For example, TMEM119 promotes cancer cell proliferation, migration, and invasion in gastric and ovarian cancers, while also inhibiting apoptosis .
